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Erucamide from Radish Leaves Has an Inhibitory Effect Against Acetylcholinesterase and Prevents Memory Deficit Induced by Trimethyltin

Journal of Medicinal Food 2018년 21권 8호 p.769 ~ 776
김초롱, 김회석, 최수정, 김재겸, 김민철, 김연정, 신동훈,
소속 상세정보
김초롱 ( Kim Cho-Rong ) - korea university Department of Food and Biotechnology
김회석 ( Kim Hoi-Suk ) - korea university Department of Food and Biotechnology
최수정 ( Choi Soo-Jung ) - Korea University Functional Food Research Center
김재겸 ( Kim Jae-Kyeom ) - University of Arkansas School of Human Environmental Sciences
김민철 ( Gim Min-Chul ) - korea university Department of Food and Biotechnology
김연정 ( Kim Youn-Jung ) - Kyung Hee University College of Nursing Science
신동훈 ( Shin Dong-Hoon ) - korea university Department of Food and Biotechnology

Abstract


In this study, we investigated a potent acetylcholinesterase inhibitor that was isolated from radish leaf (Raphanus sativus L.) extracts. Through sequential fractionation of radish leaf extract, the active constituent was identified as cis-13-docosenamide (erucamide). To validate the potency, erucamide derived from radish leaves was supplemented in diets and then fed to trimethyltin (TMT)-exposed mice. Specifically, mice had free access to a control diet or diets containing different concentrations of erucamide for 3 weeks, followed by an injection of TMT (2.5?mg/kg body weight). Our results showed that pretreatment of mice with erucamide (20 and 40?mg/kg body weight per day) significantly attenuated the TMT-induced learning and memory deficits that were assessed by Y-maze and passive avoidance tests. These findings suggest that radish leaves, and possibly its isolated erucamide, may have preventive effects against memory deficits related to Alzheimer's disease by modulation of cholinergic functions.

키워드

acetylcholinesterase inhibitory constituent; Alzheimer's disease; erucamide; memory deficit; radish leaves; trimethyltin

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