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Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses

Journal of Medicinal Food 2018년 21권 8호 p.777 ~ 784
Makau Juliann Nzembi, Watanabe Ken, Mohammed Magdy M. D., Nishida Noriyuki,
소속 상세정보
 ( Makau Juliann Nzembi ) - Nagasaki University Graduate School of Biomedical Sciences Department of Molecular Microbiology and Immunology
 ( Watanabe Ken ) - Nagasaki University Graduate School of Biomedical Sciences Department of Molecular Microbiology and Immunology
 ( Mohammed Magdy M. D. ) - National Research Centre Department of Pharmacognosy
 ( Nishida Noriyuki ) - Nagasaki University Graduate School of Biomedical Sciences Department of Molecular Microbiology and Immunology

Abstract


The high propensity of influenza viruses to develop resistance to antiviral drugs necessitates the continuing search for new therapeutics. Peanut skins, which are low-value byproducts of the peanut industry, are known to contain high levels of polyphenols. In this study, we investigated the antiviral activity of ethanol extracts of peanut skins against various influenza viruses using cell-based assays. Extracts with a higher polyphenol content exhibited higher antiviral activities, suggesting that the active components are the polyphenols. An extract prepared from roasted peanut skins effectively inhibited the replication of influenza virus A/WSN/33 with a half maximal inhibitory concentration of 1.3?μg/mL. Plaque assay results suggested that the extract inhibits the early replication stages of the influenza virus. It demonstrated activity against both influenza type A and type B viruses. Notably, the extract exhibited a potent activity against a clinical isolate of the 2009 H1N1 pandemic, which had reduced sensitivity to oseltamivir. Moreover, a combination of peanut skin extract with the anti-influenza drugs, oseltamivir and amantadine, synergistically increased their antiviral activity. These data demonstrate the potential application of peanut skin extract in the development of new therapeutic options for influenza management.

키워드

anti-influenza activity; drug resistance; functional foods; natural products; polyphenols

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