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Posttreatment Effects of Olea Europaea L. Leaf Extract on Carbon Tetrachloride-Induced Liver Injury and Oxidative Stress in Rats

Journal of Medicinal Food 2018년 21권 9호 p.899 ~ 904
Ustuner Derya, Colak Emine, Dincer Murat, Tekin Neslihan, Donmez Dilek Burukoglu, Akyuz Fahrettin, Colak Ertugrul, Kolac Umut Kerem, Entok Emre, Ustuner Mehmet Cengiz,
소속 상세정보
 ( Ustuner Derya ) - Eskisehir Osmangazi University Vocational School of Health Services Department of Medical Laboratory
 ( Colak Emine ) - Eskisehir Osmangazi University Department of Medical Biology
 ( Dincer Murat ) - Eskisehir Osmangazi University Faculty of Medicine Department of Medical Oncology
 ( Tekin Neslihan ) - Aksaray University Department of Biotechnology and Molecular Biology
 ( Donmez Dilek Burukoglu ) - Eskisehir Osmangazi University Faculty of Medicine Department of Histology and Embryology
 ( Akyuz Fahrettin ) - Eskisehir Osmangazi University Faculty of Medicine Department of Medical Biochemistry
 ( Colak Ertugrul ) - Eskisehir Osmangazi University Faculty of Medicine Department of Biostatistics and Medical Informatics
 ( Kolac Umut Kerem ) - Eskisehir Osmangazi University Faculty of Medicine Department of Medical Biology
 ( Entok Emre ) - Eskisehir Osmangazi University Faculty of Medicine Department of Nuclear Medicine
 ( Ustuner Mehmet Cengiz ) - Eskisehir Osmangazi University Faculty of Medicine Department of Medical Biology

Abstract


The aim of this study is to examine the therapeutic effects of Olea europaea L. leaf extract on carbon tetrachloride (CCl4)-induced liver damage in rats. In the experiments, 3- to 4-month-old 28 male Sprague?Dawley rats were divided into four groups: control, O. europaea leaf extract, CCl4, and curative. The CCl4 and curative groups received CCl4 (0.2?mL/kg) intraperitoneally for 10 days to form hepatic injury. O. europaea (80?mg/kg) leaf extract was given orally to the curative group dissolved in distilled water the following 14 days. Hepatic and antioxidant enzyme levels, p53, caspase 3, lipid peroxidation marker malondialdehyde (MDA), and also DNA fragmentation levels were determined to establish oxidative stress in hepatic cell damage and its consequences. After formation of liver damage, oral administration of the O. europaea significantly reduced CCl4-induced elevations of serum alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase levels (P?

키워드

antioxidants; DNA fragmentation; liver damage; p53

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