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Antiobesity Effects of Short-Chain Chitosan in Diet-Induced Obese Mice

Journal of Medicinal Food 2018년 21권 9호 p.927 ~ 934
도아라, 조수정, Cho Yun-Young, 권은영, 최지영, 이정현, 한영지, 김이수, Piao Zhe, 신용철, 최명숙,
소속 상세정보
도아라 ( Do Ah-Ra ) - Kyungpook National University Department of Food Science and Nutrition
조수정 ( Cho Su-Jung ) - Kyungpook National University Department of Food Science and Nutrition
 ( Cho Yun-Young ) - Amicogen Inc.
권은영 ( Kwon Eun-Young ) - Kyungpook National University Department of Food Science and Nutrition
최지영 ( Choi Ji-Young ) - Kyungpook National University Department of Food Science and Nutrition
이정현 ( Lee Jeong-Hyeon ) - Kyungpook National University Department of Food Science and Nutrition
한영지 ( Han Young-Ji ) - Kyungpook National University Department of Food Science and Nutrition
김이수 ( Kim Yi-Soo ) - Amicogen Inc.
 ( Piao Zhe ) - Amicogen Inc.
신용철 ( Shin Yong-Chul ) - Amicogen Inc.
최명숙 ( Choi Myung-Sook ) - Kyungpook National University Department of Food Science and Nutrition

Abstract


Dietary chitosan is known for its antiobesity effects by combining with bile acid and lipid droplets. When the chitosan structure is broken into short chains, the fat-binding capacity increases. The aim of this study was to compare long-chain chitosan (LC) with short-chain chitosan (SC) for their antiobesity effects in high-fat diet (HFD)-induced obese C57BL/6J mice for 12 weeks. The body weights of mice in both chitosan groups were decreased, especially in the SC group compared with the LC group. Total white adipose tissue and visceral fat weights were also decreased in mice of the SC group more than those of the HFD group. Moreover, SC supplementation lowered plasma triglyceride (TG) and cholesterol levels, whereas LC only lowered plasma free fatty acid level. Fecal lipids were increased in mice of both LC and SC groups, and hepatic TG and cholesterol levels were decreased in both groups. SC lowered phosphatidate phosphohydrolase activity and elevated β-oxidation in the liver. Furthermore, SC decreased the expression of the hepatic lipid-regulating genes, including fatty acid synthase, peroxisome proliferator-activated receptor (PPAR)γ1, and PPARγ2; and increased the expression of carnitine palmitoyl transferase 1α and peroxisome proliferator-activated receptor γ coactivator (PGC)1α genes. In conclusion, we demonstrated that long-term supplementation of SC can ameliorate body weight and lipid levels by increasing lipid excretion and regulating lipid metabolism, including some enzyme activities and gene expression levels, in HFD-induced obese mice.

키워드

antiobesity; diet-induced obese mice; short-chain chitosan

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