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Antiobesity Effect of Fermented Chokeberry Extract in High-Fat Diet-Induced Obese Mice

Journal of Medicinal Food 2018년 21권 11호 p.1113 ~ 1119
김나현, 제갈종환, 김윤나, 정동민, 허정두, 노정래, 양민혜, 정은주,
소속 상세정보
김나현 ( Kim Na-Hyun ) - Korea Institute of Toxicology
제갈종환 ( Jegal Jong-Hwan ) - Pusan National University College of Pharmacy
김윤나 ( Kim Yun-Na ) - Gyeongnam National University of Science and Technology Department of Agronomy & Medicinal Plant Resources
정동민 ( Chung Dong-Min ) - Samheung Agricultural Co. Ltd.
허정두 ( Heo Jeong-Doo ) - Korea Institute of Toxicology
노정래 ( Rho Jung-Rae ) - Kunsan National University Department of Oceanography
양민혜 ( Yang Min-Hye ) - Pusan National University College of Pharmacy
정은주 ( Jeong Eun-Ju ) - Gyeongnam National University of Science and Technology Department of Agronomy & Medicinal Plant Resources

Abstract


Black-fruited chokeberries (Aronia melanocarpa), growing mainly in the Central and Eastern European countries, have health benefits due to the high concentrations of polyphenolic compounds. However, a strong bitter taste of chokeberries limits its usage as functional food. We hypothesized that the fermented A. melanocarpa with a reduced bitter taste would improve insulin sensitivity and/or ameliorate weight gain induced by high-fat diet (HFD) in male C57BL/6J mice. The mice were administered with HFD together with the 100?mg/kg of natural A. melanocarpa (T1) or the fermented A. melanocarpa (T2) for 8 weeks. The treatment with T2 (100?mg/kg body weight, p.o.) markedly attenuated the weight gain and the increase in serum triglyceride level induced by HFD. The T2-treated group had better glucose tolerance and higher insulin sensitivity as measured by oral glucose tolerance test and intraperitoneal insulin tolerance test in comparison to the T1-treated group. Phytochemical analysis revealed that the main constituents of T2 were cyanidin-3-xyloside and 1-(3′,4′-dihydroxycinnamoyl)cyclopenta-2,3-diol, and the content of cyanidin glycosides (3-glucoside, 3-xyloside) was significantly reduced during the fermentation process. From the above results, we postulated that antiobesity effect of black chokeberry was not closely correlated with the cyanidin content. Fermented chokeberry might be a viable dietary supplement rich in bioactive compounds useful in preventing obesity.

키워드

aronia berries; fermentation; high-fat diet-induced obesity; glucose intolerance; insulin resistance; phytochemical analysis

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