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Polysaccharide-Rich Extract of Phragmites rhizome Attenuates Water Immersion Stress and Forced Swimming Fatigue in Rodent Animal Model

Journal of Medicinal Food 2019년 22권 4호 p.355 ~ 364
정윤희, 박태광, 임성혁, 이종혁, 방준석, 신용규, 배진형, 심상수, 황광우, 신장일, Im Wi-Joon, Khin Phyu Phyu, 이재휘, 민영실, 정지훈, 손의동,
소속 상세정보
정윤희 ( Chung Yoon-Hee ) - Chung-Ang University College of Medicine
박태광 ( Park Tae-Kwang ) - Chung-Ang University College of Medicine
임성혁 ( Yim Sung-Hyuk ) - Chung-Ang University College of Medicine
이종혁 ( Lee Jong-Hyuk ) - Hoseo University College of Life and Health Science
방준석 ( Bang Joon-Seok ) - Sookmyung Women’s University College of Pharmacy
신용규 ( Shin Yong-Kyoo ) - Chung-Ang University College of Medicine
배진형 ( Bae Jin-hyung ) - Chung-Ang University College of Pharmacy Department of Pharmacology
심상수 ( Sim Sang-Soo ) - Chung-Ang University College of Pharmacy Department of Pharmacology
황광우 ( Hwang Kwang-Woo ) - Chung-Ang University College of Pharmacy Department of Pharmacology
신장일 ( Shin Chang-Yell ) - Chung-Ang University College of Pharmacy Department of Pharmacology
 ( Im Wi-Joon ) - Chung-Ang University College of Pharmacy Department of Pharmacology
 ( Khin Phyu Phyu ) - Chung-Ang University College of Pharmacy Department of Pharmacology
이재휘 ( Lee Jae-Hwi ) - Chung-Ang University College of Pharmacy Department of Pharmacology
민영실 ( Min Young-Sil ) - Jungwon University College of Convergence Science and Technology
정지훈 ( Jeong Ji-Hoon ) - Chung-Ang University College of Medicine
손의동 ( Sohn Uy-Dong ) - Chung-Ang University College of Pharmacy Department of Pharmacology

Abstract


Our study aimed to investigate the effects of the polysaccharide-rich extract of Phragmites rhizoma (PEP) against water immersion restraint (WIR) stress and forced swimming-induced fatigue. Exposure to WIR stress significantly increased the ulcer index, bleeding score, the weight of the adrenal gland, blood glucose concentrations, total cholesterol, cortisol, and creatine kinase (CK). The weight of the spleen decreased significantly. In addition, myeloperoxidase (MPO) and thiobarbituric acid-reactive substance (TBARS) were significantly upregulated by WIR stress. The antioxidative factors such as glutathione (GSH) and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the stomach were decreased by WIR stress. Alterations induced by WIR stress were effectively reversed by pretreatment with PEP. The swimming endurance capacity of mice was significantly prolonged by the oral administration of PEP. Swimming-induced fatigue significantly reduced the body weight; however, the injection of PEP inhibited the decrease of body weight. The PEP-treated group had significantly lower CK levels in plasma, an indicator of muscle damage. These results indicated that PEP has anti-stress and anti-fatigue effects, which are mediated by suppressing the hyperactivation of the hypothalamus?pituitary?adrenal axis, and antagonism of the oxidative damages induced by WIR stress and prolonged swimming times.

키워드

anti-fatigue; anti-stress; oxidative damage; polysaccharide-rich extract of Phragmites rhizoma (PEP); water immersion restraint (WIR)-induced stress

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