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Thrombin Inhibition: Preliminary Assessment of the Anticoagulant Potential of Turnera subulata (Passifloraceae)

Journal of Medicinal Food 2019년 22권 4호 p.384 ~ 392
da Luz Jefferson Romaryo Duarte, do Nascimento Thayse Evellyn Silva, de Morais Leandro Vinicius Fernandes, da Cruz Ana Katarina Menezes, de Rezende Adriana Augusto, Neto Jose Brandao, Ururahy Marcela Abbott Galvao, Luchessi Andre Ducati, Lopez Jorge A., Rocha Hugo Alexandre Oliveira, das Gracas Almeida Maria,
소속 상세정보
 ( da Luz Jefferson Romaryo Duarte ) - Federal University of Rio Grande do Norte Health Sciences Center Postgraduation Program in Health Sciences
 ( do Nascimento Thayse Evellyn Silva ) - Federal University of Rio Grande do Norte Health Sciences Center DACT Multidisciplinary Research Laboratory
 ( de Morais Leandro Vinicius Fernandes ) - Federal University of Rio Grande do Norte Health Sciences Center DACT Multidisciplinary Research Laboratory
 ( da Cruz Ana Katarina Menezes ) - Federal University of Rio Grande do Norte Biosciences Center Department of Biochemistry
 ( de Rezende Adriana Augusto ) - Federal University of Rio Grande do Norte Health Sciences Center Postgraduation Program in Health Sciences
 ( Neto Jose Brandao ) - Federal University of Rio Grande do Norte Health Sciences Center Department of Clinical Medicine
 ( Ururahy Marcela Abbott Galvao ) - Federal University of Rio Grande do Norte Health Sciences Center DACT Multidisciplinary Research Laboratory
 ( Luchessi Andre Ducati ) - Federal University of Rio Grande do Norte Health Sciences Center Postgraduation Program in Health Sciences
 ( Lopez Jorge A. ) - Tiradentes University Institute of Technology and Research
 ( Rocha Hugo Alexandre Oliveira ) - Federal University of Rio Grande do Norte Biosciences Center Department of Biochemistry
 ( das Gracas Almeida Maria ) - Federal University of Rio Grande do Norte Health Sciences Center Postgraduation Program in Health Sciences

Abstract


Cardiovascular and thromboembolic disturbances are the main causes of disease-related deaths worldwide. Regardless of the etiological factors involved in thrombus formation, coagulation is mainly activated by thrombin, one of the most important blood clotting molecules. Thus, this study evaluated the Turnera subulata leaf crude extract, its ethyl acetate fraction effect on the coagulation cascade, and its possible side effects. Their phytocomposition indicated polyphenols, mainly flavonol-3-O-glycosylate and a flavone glycoside, without in vitro and in vivo toxicity. Regarding their potential anticoagulants, results displayed partial thromboplastin and prothrombin time activation, and Xa and IIa, and thrombin inhibition by heparin II cofactor, indicating significant anticoagulant activity, suggesting direct and indirect thrombin inhibition as the main mechanism of action. Therefore, T. subulata leaf active compounds exhibit therapeutic potential required to develop phytotherapeutic formulations to assist conventional anticoagulants in clinical treatments.

키워드

clinical therapy; coagulation cascade; plant extract; polyphenols

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