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Hydrolyzed Salmon Milt Extract Enhances Object Recognition and Location Memory Through an Increase in Hippocampal Cytidine Nucleoside Levels in Normal Mice

Journal of Medicinal Food 2019년 22권 4호 p.408 ~ 415
Nakamichi Noritaka, Nakao Shunsuke, Masuo Yusuke, Koike Ayaka, Matsumura Naoto, Nishiyama Misa, Al-Shammari Aya Hasan, Sekiguchi Hirotaka, Sutoh Keita, Usumi Koji, Kato Yukio,
소속 상세정보
 ( Nakamichi Noritaka ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Nakao Shunsuke ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Masuo Yusuke ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Koike Ayaka ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Matsumura Naoto ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Nishiyama Misa ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Al-Shammari Aya Hasan ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Sekiguchi Hirotaka ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
 ( Sutoh Keita ) - Life Science Institute Co. Ltd.
 ( Usumi Koji ) - Life Science Institute Co. Ltd.
 ( Kato Yukio ) - Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences

Abstract


Salmon milt extract contains high levels of nucleic acids and has antioxidant potential. Although salmon milt extract is known to improve impaired brain function in animal models with brain disease, its effects on learning and memory ability in healthy subjects is unknown. The purpose of the present study was to clarify the effect of hydrolyzed salmon milt extract (HSME) on object recognition and object location memory under normal conditions. A diet containing 2.5% HSME induced normal mice to devote more time to exploring novel and moved objects than in exploring familiar and unmoved objects, as observed during novel object recognition and spatial recognition tests, respectively. A diet containing 2.5% nucleic acid fraction purified from HSME also induced similar effects, as measured by the same behavioral tests. This suggests that the nucleic acids may be a functional component contributing to the effects of HSME on brain function. Quantitative polymerase chain reaction analysis revealed that gene expression of the markers for brain parenchymal cells, including neural stem cells, astrocytes, oligodendrocytes, and microglia, in the hippocampi of mice on an HSME diet was higher than that in mice on a control diet. Oral administration of HSME increased concentrations of cytosine, cytidine, and deoxycytidine in the hippocampus. Overall, ingestion of HSME may enhance object recognition and object location memory under normal conditions in mice, at least, in part, via the activation of brain parenchymal cells. Our results thus indicate that dietary intake of this easily ingestible food might enhance brain function in healthy individuals.

키워드

amino acids; brain parenchymal cells; hydrolyzed salmon milt extract; nucleic acids; object location memory; object recognition memory

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