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Ameliorative Effects of Dendropanax morbifera on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in β-Amyloid-Induced Mice

Journal of Medicinal Food 2019년 22권 6호 p.587 ~ 593
김미정, 박수연, 이승현, 김용재, 김영준, 전우진, 유호건,
소속 상세정보
김미정 ( Kim Mi-Jeong ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
박수연 ( Park Soo-Yeon ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
이승현 ( Lee Seung-Hyun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
김용재 ( Kim Yong-Jae ) - J-well Biofarm Research Institute
김영준 ( Kim Young-Jun ) - korea university Department of Food and Biotechnology
전우진 ( Jun Woo-Jin ) - Chonnam National University Department of Food and Nutrition
유호건 ( Yoon Ho-Geun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology

Abstract


Alzheimer's disease accounts for the majority of dementia and shows hallmarks such as sequential cognitive dysfunction and abnormal behavior. Dendropanax morbifera (DM) has traditionally been used to treat a variety of diseases in East Asia. The aim of this study was to assess the therapeutic effects of DM on brain neuron damage and on cognitive deficit in neuronal cell induced by Aβ1?42 in mice. Treatment with DM reduced the levels of intracellular reactive oxygen species and protected against the death of neuronal cells induced by Aβ1?42 peptide. In addition, it was also found that pretreatment with DM decreased cognitive damage induced by Aβ peptide via enhancing the cholinergic system and antioxidant defense system in mice. Furthermore, the study verified that the change in the expression of both cyclic-adenosine monophosphate response element binding protein and of brain-derived neurotrophic factor in the hippocampus in Aβ peptide-treated mice was significantly ameliorated after treatment with DM. Accordingly, these results suggest that pretreatment with DM defends against oxidative stress and cognitive impairment caused by Aβ peptide.

키워드

Aβ peptide; Alzheimer's disease; brain-derived neurotrophic factor; cognitive function; Dendropanax morbifera; oxidative stress

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