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Protective Effects and Mechanisms of Pourthiaea villosa (Thunb.) Decne. Extract on Hydrogen Peroxide-Induced Skin Aging in Human Dermal Fibroblasts

Journal of Medicinal Food 2019년 22권 8호 p.841 ~ 850
최선일, 이종석, 이사라, 조봉연, 최승현, 한웅호, 심완섭, 김영철,
소속 상세정보
최선일 ( Choi Sun-il ) - Kangwon National University Department of Food Science and Biotechnology
이종석 ( Lee Jong-Seok ) - National Institute of Biological Resources
이사라 ( Lee Sa-Rah ) - National Institute of Biological Resources
조봉연 ( Cho Bong-Yeon ) - Kangwon National University Department of Food Science and Biotechnology
최승현 ( Choi Seung-Hyun ) - Kangwon National University Department of Food Science and Biotechnology
한웅호 ( Han Xionggao ) - Kangwon National University Department of Food Science and Biotechnology
심완섭 ( Sim Wan-Sup ) - Kangwon National University Department of Food Science and Biotechnology
김영철 ( Kim Young-Cheul ) - University of Massachusetts Department of Nutrition

Abstract


Skin aging is associated with increased reactive oxygen species (ROS) produced by human cells. These radicals are the main causes of skin aging, and skin cells have developed antioxidant enzymes for protection against ROS-induced damage. Antioxidants play critical roles to prevent ROS-induced aging symptoms. In this study, the antioxidant properties of Pourthiaea villosa (Thunb.) Decne. extract (PVDE) were studied. Human dermal fibroblast (HDF) cells were treated with PVDE to evaluate its antioxidant and antiaging activities and to investigate the underlying mechanisms. The identified compounds were polyols, and phenolic and flavonoid compounds from PVDE by UHPLC-LTQ-IT-MS/MS. PVDE exhibited significant antioxidant effects, as evaluated with reducing power, and ABTS and DPPH radical scavenging activity. Furthermore, PVDE treatment significantly increased antioxidant enzyme expressions and effectively blocked H2O2-induced matrix metalloproteinase activity through MAPK signaling pathways in HDFs. Therefore, these results showed that PVDE affords an advantage of being a functional natural material with antioxidant and antiaging effects for the skin.

키워드

antiaging; antioxidant; human dermal fibroblasts; MAPK pathway; Pourthiaea villosa (Thunb.) Decne

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