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The Beneficial Effects of a Polysaccharide from Moringa oleifera Leaf on Gut Microecology in Mice

Journal of Medicinal Food 2019년 22권 9호 p.907 ~ 918
Wang Fang, Bao Yi-Fan, Si Jia-Jun, Duan Yu, Weng Ze-Bin, Shen Xin-Chun,
소속 상세정보
 ( Wang Fang ) - Nanjing University of Finance and Economics College of Food Science and Engineering
 ( Bao Yi-Fan ) - Nanjing University of Finance and Economics College of Food Science and Engineering
 ( Si Jia-Jun ) - Nanjing University of Finance and Economics College of Food Science and Engineering
 ( Duan Yu ) - Nanjing University of Chinese Medicine Basic Medical College
 ( Weng Ze-Bin ) - Nanjing University of Chinese Medicine Basic Medical College
 ( Shen Xin-Chun ) - Nanjing University of Finance and Economics College of Food Science and Engineering

Abstract


Moringa oleifera is a natural plant with high nutritional and pharmacological value. Leaves of M. oleifera contain a variety of active substances. In our previous research, we had obtained a polysaccharide separated from M. oleifera leaf, namely MOs-2-a (1.35?×?104 Da). In this study, this polysaccharide was administrated daily to 6 week-old ICR mice for 4 weeks. Then, the body weight, immunity, intestinal digestion, and intestinal microenvironment of Institute of Cancer Research (ICR) mice were investigated. After 4 weeks of feeding intervention with the polysaccharide, the immune and intestinal digestive ability of the ICR mice were significant as shown by the organ index, digestive enzymes, and reduction of serum tumor necrosis factor-alpha and diamine oxidase levels. The polysaccharide could regulate the microbial composition of the intestinal tract in mice by increasing the bacteria that have been reported for antiobesity effects, short chain fatty acid production, and lactic acid production. These findings indicate that the polysaccharide of M. oleifera leaf might be a promising prebiotic that exhibits health promotion effects.

키워드

digestive enzymes; gut microbiota; M. oleifera leaf; polysaccharide; prebiotic

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