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Policosanol Attenuates Cholesterol Synthesis via AMPK Activation in Hypercholesterolemic Rats

Journal of Medicinal Food 2019년 22권 11호 p.1110 ~ 1117
남다은, 윤정문, 김다경, 김옥경,
소속 상세정보
남다은 ( Nam Da-Eun ) - University of Virginia School of Medicine Carter Immunology Center
윤정문 ( Yun Jeong-Moon ) - Kyung Hee University Research Institute of Clinical Nutrition
김다경 ( Kim Da-Kyung ) - Kyung Hee University Research Institute of Clinical Nutrition
김옥경 ( Kim Ok-Kyung ) - Chonnam National University Division of Food and Nutrition

Abstract


This study was carried out to investigate the effects of policosanol on high-fat and high-cholesterol diet-induced hypercholesterolemic rats to provide strong evidence in support of its hypocholesterolemic effect. The hypercholesterolemic rats showed elevations in liver weight, total triglycerides, total cholesterol, and low-density lipoprotein (LDL) cholesterol in serum; however, policosanol supplementation reduced these markers significantly. In addition, we found that policosanol supplementation stimulated an increase in fecal cholesterol and bile acid contents and deactivated 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase by AMP-activated protein kinase (AMPK) phosphorylation during high-fat and high-cholesterol?containing diet-induced development of hypercholesterolemia. Policosanol supplementation decreased ApoB levels and increased LDL-receptor expression, but it did not affect the hepatic ACAT2 level in livers from hypercholesterolemic rats. Moreover, supplementation with policosanol significantly decreased aortic wall thickness and levels of P-selectin and soluble vascular cell adhesion molecule (sVCAM-1) in serum. In conclusion, we suggest that policosanol supplementation induces antihypercholesterolemia by inhibiting cholesterol biosynthesis, LDL cholesterol uptake, and cholesterol excretion.

키워드

AMPK; HMG-CoA reductase; hypercholesterolemia; LDL cholesterol; policosanol

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