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The Beneficial Effects of Raffinee in Permanent Occulted Stroke Mice

Journal of Medicinal Food 2019년 22권 12호 p.1226 ~ 1234
Chiu Chun-Ching, Lin Jer-Min, Wu Li-Yi, Hsu Tsai-Ching, Tzang Bor-Show,
소속 상세정보
 ( Chiu Chun-Ching ) - Chung Shan Medical University Institute of Biochemistry, Microbiology and Immunology
 ( Lin Jer-Min ) - Ziel Enterprise Co. Ltd.
 ( Wu Li-Yi ) - Chung Shan Medical University Institute of Biochemistry, Microbiology and Immunology
 ( Hsu Tsai-Ching ) - Chung Shan Medical University Institute of Biochemistry, Microbiology and Immunology
 ( Tzang Bor-Show ) - Chung Shan Medical University Institute of Biochemistry, Microbiology and Immunology

Abstract


Ischemic stroke is a major cause of disability and mortality globally. Although thrombolytic therapy is routinely adopted in cases of ischemic stroke, various alternative natural neuroprotectants are also used as effective adjuvant therapies to recover neurofunction following ischemic stroke. Raffinee, a natural fermented product with strong antioxidant and neuroprotective activities, has antiatherogenic effects in animals and has exhibited neuroprotective effects in a clinical trial by recovering motor and sensory function following spinal cord lesion. This study reveals the advantageous effects of Raffinee on PC12 cells by decreasing hypoxia-induced apoptosis in mice with permanent middle cerebral artery occlusion (pMCAO) by increasing the levels of neurotrophic factors such as S100β, reducing serum inflammatory factors such as matrix metalloproteinases (MMP)-9/MMP-2 ratio, tumor necrosis factor-α, and interleukin (IL)-6 level, and increasing IL-10 levels. Significantly reduced brain infarct volume along with a favorable survival ratio was observed for pMCAO mice that received Raffinee, suggesting a neuroprotective potential of Raffinee in cases of acute ischemic stroke by suppressing apoptosis.

키워드

inflammatory cytokines; ischemic stroke; permanent middle cerebral artery occlusion; Raffinee

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