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Water Extract of Yamato Tachibana (Citrus tachibana) Induces Food Intake in Adult and Larval Zebrafish

Journal of Medicinal Food 2020년 23권 1호 p.65 ~ 71
Yamada Yuka, Chensom Sasicha, Yonemoto Hisataka, Nakayama Hiroko, Zang Liqing, Nishimura Norihiro, Mishima Takashi, Shimada Yasuhito,
소속 상세정보
 ( Yamada Yuka ) - Mie University Graduate School of Regional Innovation Studies
 ( Chensom Sasicha ) - Mie University Graduate School of Regional Innovation Studies
 ( Yonemoto Hisataka ) - Mie University Graduate School of Medicine Department of Integrative Pharmacology
 ( Nakayama Hiroko ) - Mie University Graduate School of Regional Innovation Studies
 ( Zang Liqing ) - Mie University Graduate School of Regional Innovation Studies
 ( Nishimura Norihiro ) - Mie University Graduate School of Regional Innovation Studies
 ( Mishima Takashi ) - Mie University Graduate School of Bioresources
 ( Shimada Yasuhito ) - Mie University Graduate School of Medicine Department of Integrative Pharmacology

Abstract


Yamato Tachibana (Tachibana; Citrus tachibana) is an endemic fruit and represents one of the oldest citrus species in Japan; it is grown in the Mie Prefecture. It has been attracting attention for its cultural heritage and unique scent. To evaluate biological activities of Tachibana, we fed several parts of the Tachibana fruit (whole fruit, pulp [albedo and segment wall], and flavedo) to adult zebrafish and found that Tachibana increased body weight and plasma triglycerides besides increasing overall food intake. We then created a simple fluorescence-based feeding assay using dried rotifer sheets and larval zebrafish (6 days postfertilization) to screen the various extracts of Tachibana parts. We found that water extracts of Tachibana pulp increased feeding volume in zebrafish. Although citrus species are believed to prevent obesity and obesity-associated diseases in general, our findings showed that water extracts of Tachibana increase food intake in zebrafish and lead to an increase in body weight. We suggest that Tachibana might reverse appetite loss in lean populations and may prove beneficial in aiding fish cultivation.

키워드

appetite; nutritional composition; weight gain; zebrafish

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