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Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules-A Meta-Analysis

Journal of Medicinal Food 2020년 23권 2호 p.101 ~ 113
Bertuccioli Alexander, Moricoli Sara, Amatori Stefano, Rocchi Marco Bruno Luigi, Vici Giorgia, Sisti Davide,
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 ( Bertuccioli Alexander ) - University of Urbino Carlo Bo School of Biomedical Sciences Department of Biomolecular Sciences
 ( Moricoli Sara ) - University of Urbino Carlo Bo School of Biomedical Sciences Department of Biomolecular Sciences
 ( Amatori Stefano ) - University of Urbino Carlo Bo Department of Biomolecular Sciences
 ( Rocchi Marco Bruno Luigi ) - University of Urbino Carlo Bo Department of Biomolecular Sciences
 ( Vici Giorgia ) - University of Camerino School of Biosciences and Veterinary Medicine
 ( Sisti Davide ) - University of Urbino Carlo Bo Department of Biomolecular Sciences

Abstract


The aim of this study was to analyze the efficacy of berberine taken alone or in other formulations (with silymarin or other mixtures) on dyslipidemia through a systematic review of the literature and a meta-analysis. A systematic investigation was conducted on 19 studies that were selected based on inclusion and exclusion criteria. Both controlled trials (n?=?12) and cross-sectional trials (n?=?7) were included. The following formulations were examined: berberine used alone (n?=?5), berberine combined with silymarin (n?=?8), and other mixture containing berberine (n?=?6). A meta-analysis was performed using a fixed-effects model and meta-regression. Total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides were considered. Moreover, possible associations of each parameter with age and the dose and duration of the treatment were analyzed. The data obtained showed a significant reduction in TC and LDL cholesterol for each formulation. A reduction in triglycerides was also observed for both TC and LDL but with a smaller impact. As regards HDL, a slight increase was observed, but it was not statistically significant. The formulation of berberine in association with silymarin was found to have the greatest impact on TC, LDL, HDL, and triglycerides. The greater efficacy of the formulation consisting of berberine associated with silymarin can probably be accounted for by the fact that the latter increases the bioavailability of berberine. However, it is necessary to carry out further clinical studies to better define the efficacy of the treatment and which patients show the best response.

키워드

HDL; LDL; total cholesterol; triglycerides

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