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Graviola Fruit Bar Added Acerola By-Product Extract Protects Against Inflammation and Nociception in Adult Zebrafish (Danio rerio)

Journal of Medicinal Food 2020년 23권 2호 p.173 ~ 180
da Silva Larissa Morais Ribeiro, da Silva Severino Lima Jorgiane, Magalhaes Franscisco Ernani Alves, Campos Adriana Rolim, de Araujo Jose Ismael Feitosa, Batista Francisco Lucas Alves, de Araujo Sandra Maria Barbosa, de Sousa Paulo Henrique Machado, Lima Glauber Cruz, Holanda Dayse Karine Rodrigues,
소속 상세정보
 ( da Silva Larissa Morais Ribeiro ) - Federal University of Ceara Department of Food Engineering
 ( da Silva Severino Lima Jorgiane ) - Federal University of Ceara Department of Food Engineering
 ( Magalhaes Franscisco Ernani Alves ) - Laboratory of Bioprospection of Natural Products and Biotechnology
 ( Campos Adriana Rolim ) - University of Fortaleza Center of Experimental Biology
 ( de Araujo Jose Ismael Feitosa ) - Laboratory of Bioprospection of Natural Products and Biotechnology
 ( Batista Francisco Lucas Alves ) - Laboratory of Bioprospection of Natural Products and Biotechnology
 ( de Araujo Sandra Maria Barbosa ) - Laboratory of Bioprospection of Natural Products and Biotechnology
 ( de Sousa Paulo Henrique Machado ) - Federal University of Ceara Culture and Art Institute
 ( Lima Glauber Cruz ) - State University of Ceara Faculty of Medicine
 ( Holanda Dayse Karine Rodrigues ) - Federal University of Ceara Department of Food Engineering

Abstract


Studies involving foods associated with pain reversal and anti-inflammatory effects using zebrafish are rarely reported in the literature. This study aimed to evaluate the effect of graviola (Annona muricata L.) fruit bar (GFB) and GFB added with acerola (Malpighia glabra L) seed extract (ASE) on acute nociception and abdominal inflammation in adult zebrafish (Danio rerio). Acute nociception was induced by formalin, capsaicin, cinnamaldehyde, acidic saline, glutamate (cutaneous models), and hypertonic saline (corneal model), and inflammation was induced by carrageenan. Both GFB and ASE exhibited antinociceptive effect modulated by the nitrergic system, guanylate cyclase, and transient receptor potential ankyrin 1 and acid-sensing ion channels. The antinociceptive effect of GFB also appears to be modulated by the opioid system and glutamatergic receptors (N-methyl-D-aspartate receptor). Only ASE presented corneal antinociceptive effect. Both samples showed anti-inflammatory effect, being more significant the effect of GFB. The addition of acerola by-product extract in GFB results in a product with greater biological potential.

키워드

adult zebrafish (Danio rerio); Annona muricata L.; inflammation; Malpighia glabra L.; nociception

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