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A Combination of Korean Red Ginseng Extract and Glycyrrhiza glabra L. Extract Enhances Their Individual Anti-Obesity Properties in 3T3-L1 Adipocytes and C57BL/6J Obese Mice

Journal of Medicinal Food 2020년 23권 3호 p.215 ~ 223
Zheng Yulong, 이재선, 이은혜, 인교, 김종한, 이미향, 이옥환, 강일준,
소속 상세정보
 ( Zheng Yulong ) - Hallym University Department of Food Science and Nutrition
이재선 ( Lee Jae-Sun ) - Hallym University Department of Food Science and Nutrition
이은혜 ( Lee Eun-Hye ) - Hallym University Department of Food Science and Nutrition
인교 ( In Gyo ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
김종한 ( Kim Jong-Han ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
이미향 ( Lee Mi-Hyang ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
이옥환 ( Lee Ok-Hwan ) - Kangwon National University Department of Food Science and Biotechnology
강일준 ( Kang Il-Jun ) - Hallym University Department of Food Science and Nutrition

Abstract


Anti-obesity activities of Korean red ginseng saponin fraction (RGS) and/or Glycyrrhiza glabra L. extract (GG) were investigated in 3T3-L1 adipocytes and high-fat diet-induced C57BL/6J obese mice. RGS and GG extracts were mixed at a mass ratio of 3:1 (SG31), 1:1 (SG11), or 1:3 (SG13). SG31 showed the highest anti-obesity activity among the three different mass ratios of RGS and GG extracts. SG31 showed higher inhibition efficiency on triglyceride (TG) accumulation than either single extract in 3T3-L1 adipocytes and without any cytotoxicity. It also decreases the expression of adipogenic and lipogenic genes such as C/EBPα and SREBP-1c (sterol regulatory element-binding protein 1c). In the obese induced mouse model, SG31 significantly reduced white adipose tissue weight and body weight, attenuated dyslipidemia, and decreased serum TG levels. In some indices, the activity of SG31 was even higher compared with Garcinia Cambogia water extract, a positive control. The possible mechanism by which SG31 causes the above results was by activating the AMP-activated protein kinase (AMPK) pathway and stimulating the secretion of adiponectin in adipose tissue to regulate energy metabolism balance, inhibit TG formation, and promote β-oxidation of fatty acids. Therefore, SG31 may have efficacy as an anti-obesity functional food or raw material if the results can be confirmed in human studies.

키워드

additive effect; AMPK pathway; extract mixture; obesity; transcription factor

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