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Young Persimmon Fruit Extract Suppresses Obesity by Modulating Lipid Metabolism in White Adipose Tissue of Obese Mice

Journal of Medicinal Food 2020년 23권 3호 p.273 ~ 280
김민영, 신미래, 서부일, 노정숙, 노성수,
소속 상세정보
김민영 ( Kim Min-Yeong ) - Daegu Haany University College of Korean Medicine Department of Herbology
신미래 ( Shin Mi-Rae ) - Daegu Haany University College of Korean Medicine Department of Herbology
서부일 ( Seo Bu-Il ) - Daegu Haany University College of Korean Medicine Department of Herbology
노정숙 ( Noh Jeong-Sook ) - Tongmyong University Department of Food Science & Nutrition
노성수 ( Roh Seong-Soo ) - Daegu Haany University College of Korean Medicine Department of Herbology

Abstract


Young persimmon fruit (YPF) has recently been reported to have a regulatory effect on lipid metabolism. The aim of this study was to investigate whether the YPF aqueous extract (YPFE) exert an antiobesity effect by modulating lipid metabolism in the white adipose tissue (WAT) of obese C57BLKS/J db/db mice. YPFE (100 or 200?mg/kg body weight/day) or distilled water as a vehicle was orally administered by gavage to 12-week-old obese male db/db mice for 3 weeks (n?=?7 for each group). YPFE administration significantly reduced body weight and WAT size. Furthermore, YPFE considerably reduced triglyceride and cholesterol concentrations in serum and WAT. Obese vehicle treated mice exhibited an enhanced protein expression of adipogenic and lipogenic genes. However, this increased expression was alleviated in the YPFE-fed groups, resulting in inhibition of adipogenesis and downregulation of fatty acid synthesis. In addition, there was an increase in the level of transcription factors associated with fatty acid oxidation in the YPFE-treated group. In obese mice, the expression of proteins associated with cholesterol metabolism was augmented. YPFE did not affect cholesterol synthesis, but cholesterol efflux-related proteins were significantly upregulated. YPF exerts beneficial effects on obesity by inhibiting adipogenesis and reducing lipid synthesis and accumulation by regulation of lipid-related transcription factors in the WAT of obese mice.

키워드

ABCA1; adipogenesis; adipose tissue; db/db mice; persimmon fruit; PPAR; SREBP

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