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Physalis alkekengi Exhibits Antiobesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning

Journal of Medicinal Food 2020년 23권 3호 p.312 ~ 318
Lee Yuan Yee, 김민기, Irfan Muhammad, 김승형, 김성대, 이만휘,
소속 상세정보
 ( Lee Yuan Yee ) - Kyungpook National University College of Veterinary Medicine
김민기 ( Kim Min-Ki ) - Kyungpook National University College of Veterinary Medicine
 ( Irfan Muhammad ) - Kyungpook National University College of Veterinary Medicine
김승형 ( Kim Seung-Hyung ) - Daejeon University Institute of Traditional Medicine and Bioscience
김성대 ( Kim Sung-Dae ) - Dongnam Institute of Radiological and Medical Sciences Research Center
이만휘 ( Rhee Man-Hee ) - Kyungpook National University College of Veterinary Medicine

Abstract


The aim of this study was to investigate the efficacy of an ethanol extract of Physalis alkekengi (PA) and its mechanistic pathway of action at the molecular level for its antiobesity properties. Four-week old male Institute of Cancer Research (ICR) mice were acclimatized for a week before starting the high-fat diet (HFD) for 2 weeks to induce obesity, followed by 8 more weeks of oral administration of 10?mg/kg orlistat and 300?mg/kg of PA extract, along with HFD. Body weights of the mice and feed and water intake were recorded weekly. After a total of 12 weeks, mice were euthanized, and blood, liver, and adipose tissues were harvested for further analysis. Administration of PA extract inhibited the progression of obesity by reducing weight gain, weight of adipose tissue, and normalizing serum triglyceride, glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein, alanine aminotransferase, and aspartate aminotransferase. PA extract prevented the progression of nonalcoholic steatohepatitis induced by HFD and prevented the enlargement of liver. Phosphorylation of adenosine monophosphate-activated protein kinase α increased while phosphorylation of acetyl-CoA carboxylase was reduced. The browning gene uncoupling protein 1 expression was also increased by PA extract treatment. Our findings revealed that the antiobesity properties of PA extract may be mediated by browning of white adipose tissue.

키워드

antiobesity; browning gene; high-fat diet; Physalis alkekengi; UCP-1

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