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Patchouli Alcohol, a Compound from Pogostemon cablin, Inhibits Obesity

Journal of Medicinal Food 2020년 23권 3호 p.326 ~ 334
이지혜, 공병휘, 이성호,
소속 상세정보
이지혜 ( Lee Ji-Hye ) - USA University of Maryland Department of Nutrition and Food Science
공병휘 ( Kong Byung-Whi ) - University of Arkansas Department of Poultry Science
이성호 ( Lee Seong-Ho ) - USA University of Maryland Department of Nutrition and Food Science

Abstract


Obesity predisposes people to a variety of chronic metabolic diseases. Identification of natural factors that prevent the development of obesity is likely to be the most successful means of ameliorating the current obesity epidemic. Patchouli alcohol is a sesquiterpene alcohol found in Pogostemon cablin and possesses health benefit activities. This study was designed to examine if patchouli alcohol affects adipogenesis, and investigates the underlying mechanisms whereby patchouli alcohol exerts antiobesity effect. 3T3-L1 adipocytes were differentiated with treatment of different concentrations of patchouli alcohol. An in vivo study was performed to test the effect of patchouli alcohol gavage on a high-fat diet (HFD)-induced obesity. Treatment of patchouli alcohol reduced lipid accumulation in 3T3-L1 adipocytes in a dose-dependent manner without toxicity. Regarding mechanism, treatment of patchouli alcohol reduced expression of peroxisome proliferator-activated receptor-gamma (PPARγ) and CCAAT-enhancer-binding protein-alpha (C/EBPα) and increased expression of total and active β-catenin in 3T3-L1 adipocytes. Oral gavage of patchouli alcohol led to a significant reduction of body weight and fat accumulation in the mice fed with HFD. Transcriptome analysis indicates that smad7 is most highly activated gene in patchouli alcohol-treated 3T3-L1 cells. Patchouli alcohol possesses health benefit effect through inhibiting adipogenesis and fat tissue development.

키워드

adipogenesis; high-fat diet; obesity; patchouli alcohol

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