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Fresh Saengshik Showed a Positive Effect on Mitigating Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

Journal of Medicinal Food 2020년 23권 4호 p.459 ~ 464
송가락, 신선호, 박미현, 황성주, 주재현, 김희영, 권미라, 박건영,
소속 상세정보
송가락 ( Song Jia-Le ) - China Guilin Medical University School of Public Health Department of Nutrition and Food Hygiene
신선호 ( Shin Sung-Ho ) - Pusan National University Department of Food Science and Nutrition
박미현 ( Park Mi-Hyun ) - Erom R&D Center
황성주 ( Hwang Sung-Joo ) - Erom R&D Center
주재현 ( Ju Jae-Hyun ) - CHA University Department of Food Science and Biotechnology
김희영 ( Kim Hee-Young ) - Pusan National University Korean Medicine Research Center for Healthy Aging
권미라 ( Kweon Mee-Ra ) - Pusan National University Department of Food Science and Nutrition
박건영 ( Park Kun-Young ) - CHA University Department of Food Science and Biotechnology

Abstract


This study was to compare the anticolitis activity of fresh Saengshik (FSS) with heated Saengshik (HSS) with dextran sulfate sodium (DSS)-induced experimental colitis mouse model. Both FSS- and HSS-fed colitis mice exhibited the effects of the increase in the body weight, the alleviation in the colon shortening, and the reduction of the ratio of colon weight to length. However, FSS-fed colitis mice showed a much more significant decrease in DSS-induced tissue damage by mucosal edema and crypt deficiency than did HSS-fed ones. Besides, FSS contributed to decreasing the serum levels of proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-1 beta) and inhibiting the colonic mRNA expressions of these cytokines in colitis tissue of the mice. FSS also resulted in the lower colonic mRNA expression level of inflammation-related inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in colitis mice than did HSS. Overall results confirmed Saengshik, especially FSS, inhibits more effectively against DSS-induced inflammation reaction in colitis mice than HSS.

키워드

colitis; cytokines; inflammation; iNOS and COX-2; Saengshik

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