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Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera

Journal of Medicinal Food 2020년 23권 5호 p.465 ~ 475
Kojima-Yuasa Akiko, Matsui-Yuasa Isao,
소속 상세정보
 ( Kojima-Yuasa Akiko ) - Osaka City University Graduate School of Human Life Science Department of Food and Human Health Sciences
 ( Matsui-Yuasa Isao ) - Osaka City University Graduate School of Human Life Science Department of Food and Human Health Sciences

Abstract


1′-Acetoxychavicol acetate (ACA) is found in the rhizomes or seeds of Alpinia galanga and Alpinia conchigera, which are used as traditional spices in cooking and traditional medicines in Southeast Asia. ACA possesses numerous medicinal properties. Those include anticancer, antiobesity, antiallergy, antimicrobial, antidiabetic, gastroprotective, and anti-inflammatory activities. ACA is also observed to exhibit antidementia activity. Recent studies have demonstrated that combining ACA with other substances results in synergistic anticancer effects. The structural factors that regulate the activity of ACA include (1) the acetyl group at position 1′, (2) the acetyl group at position 4, and (3) the unsaturated double bond between positions 2′ and 3′. ACA induces the activation of AMP-activated protein kinase (AMPK), which regulates the signal transduction pathways, and has an important role in the prevention of diseases, including cancer, obesity, hyperlipidemia, diabetes, and neurodegenerative disorders. Such findings suggest that AMPK has a central role in different pharmacological functions of ACA, and ACA is useful for the prevention of life-threatening diseases. However, more studies should be performed to evaluate the clinical effects of ACA and to better understand its potential.

키워드

1′-Acetoxychavicol acetate; Alpinia conchigera; Alpinia galanga; AMPK; diverse pharmacological effects; structure-activity relationships; synergistic anticancer treatment effects

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