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Effervescent Glutamine Formulation Improves the Beneficial Effects of Antiretroviral Therapies on Immune Function in HIV/AIDS Carrier Patients

Journal of Medicinal Food 2020년 23권 5호 p.485 ~ 490
Krupek Tuane, Ferrari Bruna Juliana Wanczinski, da Silva Maria Angelica Raffaini Covas Pereira, Schamber Christiano Rodrigues, Bertolini Dennis Armando, Bruschi Marcos Luciano, Previdelli Isolde Terezinha Santos, Pereira Omar Cleo Neves, Dias Jose Ricardo Colleti, Curi Rui, Bazotte Roberto Barbosa,
소속 상세정보
 ( Krupek Tuane ) - State University of Maringa Postgraduate Programs in Pharmaceutical Sciences
 ( Ferrari Bruna Juliana Wanczinski ) - State University of Maringa Postgraduate Programs in Pharmaceutical Sciences
 ( da Silva Maria Angelica Raffaini Covas Pereira ) - State University of Maringa Department of Pharmacology and Therapeutics
 ( Schamber Christiano Rodrigues ) - State University of Maringa Postgraduate Programs in Pharmaceutical Sciences
 ( Bertolini Dennis Armando ) - State University of Maringa Postgraduate Programs in Health Sciences
 ( Bruschi Marcos Luciano ) - State University of Maringa Postgraduate Programs in Pharmaceutical Sciences
 ( Previdelli Isolde Terezinha Santos ) - State University of Maringa Postgraduate Programs in Biostatistics
 ( Pereira Omar Cleo Neves ) - State University of Maringa Postgraduate Programs in Biostatistics
 ( Dias Jose Ricardo Colleti ) - Aids Center of Maringa City Public Service Health Care for Sexually Transmitted Diseases
 ( Curi Rui ) - Cruzeiro do Sul University Interdisciplinary Postgraduate Program in Health Sciences
 ( Bazotte Roberto Barbosa ) - State University of Maringa Postgraduate Programs in Pharmaceutical Sciences

Abstract


The impact of oral supplementation with an effervescent glutamine formulation on the beneficial effects of antiretroviral therapies was evaluated in people living with HIV/AIDS. For this purpose, 12 HIV/AIDS carrier patients with CD4+ T cell counts <500, and who had received the same antiretroviral therapy for at least 1 year before starting this investigation were selected. The patients were required to dissolve the effervescent glutamine formulation (supplied in sachets) in water immediately before oral ingestion (12.4?g), once a day, after lunch or after dinner during 30 days. CD4+ T cell counts, complete blood cell counts, serum cytokines, and amino acids levels were quantified; biochemical and toxicological measurements were performed. The numbers of CD4+ T cells were increased (P?

키워드

CD4+ T cell; cytokines; effervescent formulation; inflammation; nutraceuticals

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