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Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity

Journal of Medicinal Food 2020년 23권 6호 p.633 ~ 640
이수연, 김미정, 장수빈, 이경은, 황수연, 권영주, 홍정연, 손명현, 박수연, 유호건,
소속 상세정보
이수연 ( Lee Soo-Yeon ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
김미정 ( Kim Mi-Jeong ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
장수빈 ( Jang Su-Bhin ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
이경은 ( Lee Gyeong-Eun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
황수연 ( Hwang Soo-Yeon ) - Ewha Womans University College of Pharmacy
권영주 ( Kwon Young-Joo ) - Ewha Womans University College of Pharmacy
홍정연 ( Hong Jung-Yeon ) - Yonsei University College of Medicine Department of Pediatrics
손명현 ( Sohn Myung-Hyun ) - Yonsei University College of Medicine Department of Pediatrics
박수연 ( Park Soo-Yeon ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
유호건 ( Yoon Ho-Geun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology

Abstract


Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity. Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases. Plumbagin treatment significantly suppressed transforming growth factor-β-induced profibrotic target-gene expression and proliferation of fibroblast cell lines. Moreover, plumbagin significantly inhibited bleomycin-induced pulmonary fibrosis in mice. Taken together, these data demonstrate the inhibitory effects of plumbagin on lung fibrosis and its promise as a therapeutic agent for IPF.

키워드

histone acetyltransferase; p300; plumbagin; pulmonary fibrosis

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