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Combination of Sargassum fusiforme and Pueraria lobata Extracts Alleviates Postmenopausal Symptoms in Ovariectomized Rats

Journal of Medicinal Food 2020년 23권 7호 p.735 ~ 744
이민희, 박수정, 문윤정, 인교, 김종한, 김성원, 이미향, 김옥경,
소속 상세정보
이민희 ( Lee Min-hee ) - Kyung Hee University Research Institute of Clinical Nutrition
박수정 ( Park Soo-Jeung ) - Kyung Hee University Research Institute of Clinical Nutrition
문윤정 ( Moon Yun-Jeong ) - Kyung Hee University Research Institute of Clinical Nutrition
인교 ( In Gyo ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
김종한 ( Kim Jong-Han ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
김성원 ( Kim Sung-Won ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
이미향 ( Lee Mi-Hyang ) - Korea Ginseng Corporation Korea Ginseng Corporation Research Institute
김옥경 ( Kim Ok-Kyung ) - Chonnam National University Division of Food and Nutrition

Abstract


Estrogen, produced mainly in the ovaries, plays a role in sexual development, metabolism, and bone formation. Thus, estrogen deficiency due to menopause can lead to overweight, dyslipidemia, and osteoporosis. In this study, we compared the effects of extracts of Sargassum fusiforme, Pueraria lobata, and their mixtures at various ratios on osteosarcoma SaOS-2 cells and investigated the effect of PS31 (P. lobata: S. fusiforme?=?3:1, KGC02PS) on postmenopausal symptoms in ovariectomized rats. PS31 supplementation, as little as 100?mg/kg BW, effectively reduced ovariectomy-induced weight gain, and total triglyceride, total cholesterol, and low-density lipoprotein-cholesterol concentrations in serum. In addition, PS31 supplementation prevented bone density loss, inhibited bone resorption, and reduced the expression of catabolic factors in bone. However, PS31 supplementation did not affect uterus weight and expression of c-Jun and c-Fos, which suggests that the mechanism of action of PS31 is distinct from that of estrogen. Taken together, we demonstrated that PS31 supplementation alleviated postmenopausal symptoms, including overweight, dyslipidemia, and osteoporosis. Therefore, PS31 could be potentially used as food supplement to prevent postmenopausal symptoms.

키워드

dyslipidemia; menopause; ovariectomized rats; Pueraria lobata; Sargassum fusiforme

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