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Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease

Journal of Medicinal Food 2020년 23권 7호 p.760 ~ 771
이주영, 임아랑, 심기석, 지건영, 김기모, 김윤희, 채성욱,
소속 상세정보
이주영 ( Lee Joo-Young ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
임아랑 ( Im A-Rang ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
심기석 ( Shim Ki-Shuk ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
지건영 ( Ji Kon-Young ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
김기모 ( Kim Ki-Mo ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
김윤희 ( Kim Yun-Hee ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
채성욱 ( Chae Sung-Wook ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division

Abstract


It is well known that nonalcoholic fatty liver disease (NAFLD) is a common disease worldwide because of unhealthy changes in dietary habits. In this study, we determined the effects of Tenebrio molitor Linnaeus, 1758 extract (TML) and Allomyrina dichotoma Linnaeus, 1771 larvae extract (ADL) in cellular and animal models. In vitro, TML and ADL treatments did not cause cytotoxicity, but attenuated the accumulation of lipid in HepG2 cells induced by free fatty acids. In vivo, mice were orally treated with TML and ADL for 10 weeks during high-fat diet feeding. TML and ADL administration significantly reduced the weight of body, liver tissue, and adipose tissue. Serum lipid profiles, hepatic functional parameters, and glucose levels were ameliorated by TML and ADL. Moreover, TML and ADL suppressed increased lipogenesis and inflammation-related makers, and improved antioxidant enzyme activity. In liver tissue, the decreased lipid accumulation by administration of TML and ADL was observed using Oil Red O and Hematoxylin and Eosin staining. Therefore, we suggest that TML and ADL may be having a therapeutic potential and is used to develop a therapeutic agent for NAFLD.

키워드

Allomyrina dichotoma Linnaeus; 1771; HepG2; high fat diet; lipogenesis; lipid accumulation; Tenebrio molitor Linnaues; 1758

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