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Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study

Journal of Medicinal Food 2020년 23권 9호 p.905 ~ 919
Rao Amit S., Hegde Shyamala, Pacioretty Linda M., DeBenedetto Jan, Babish John G.,
소속 상세정보
 ( Rao Amit S. ) - Supreem Pharmaceuticals Mysore Pvt. Ltd.
 ( Hegde Shyamala ) - Supreem Pharmaceuticals Mysore Pvt. Ltd.
 ( Pacioretty Linda M. ) - Bio Nexus Ltd.
 ( DeBenedetto Jan ) - Bio Nexus Ltd.
 ( Babish John G. ) - Bio Nexus Ltd.

Abstract


In 2019, ∼?463 million people globally had diabetes mellitus (DM), with China (25.1%), India (16.6%), and the United States (6.69%) representing nearly 50% of that total. The primary objectives of this exploratory study were to assess the safety and potential efficacy of Nigella sativa and fenugreek seed supplemented chapatis in overweight (OW) and type 2 DM subjects. Forty subjects (15/OW; 9/DM; 16/DM/OW) consumed two chapatis twice a day 6 days/week for a daily dose of 5.45?g of an N. sativa/fenugreek combination over 12 weeks with no changes in lifestyle or medications. Anthropometric, glycemic, and vascular variables were recorded at baseline and after 6 and 12 weeks. Glycated hemoglobin (HbA1c), plasma lipids, and complete metabolic profile were measured at baseline and termination. Compliance, estimated during twice-daily individual delivery of precooked chapatis, was 100%, with no significant adverse effects. At termination, body weights, body mass index, waist and hip circumferences, index of central obesity, HbA1c, fasting blood glucose, 2-h postprandial blood glucose, estimated average glucose over 12 weeks, total cholesterol (TC), non-high density lipoprotein (HDL) cholesterol, very low density lipoprotein (VLDL), and triglycerides (TG) were decreased (P?

키워드

hepatic steatosis; Nigella sativa; obesity; Trigonella foenum-graecum; type 2 diabetes

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