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Curcumin Alleviates the Side Effects of Cisplatin on Gastric Emptying of Mice by Inhibiting the Signal Changes of Acetylcholine and Interstitial Cells of Cajal

Journal of Medicinal Food 2020년 23권 9호 p.920 ~ 927
Li Hui, Xu Wenhua, Liu Xuying, Ye Junli, Li Peijie, Shang Fangfang, Yu Xiaoling,
소속 상세정보
 ( Li Hui ) - Qingdao University Medical College Department of Physiology and Pathophysiology
 ( Xu Wenhua ) - Qingdao University Medical College Department of Laboratory Biochemistry
 ( Liu Xuying ) - Qingdao University Medical College
 ( Ye Junli ) - Qingdao University Medical College Department of Physiology and Pathophysiology
 ( Li Peijie ) - Zhejiang University First Affiliated Hospital Department of Pathology
 ( Shang Fangfang ) - Navy 971 Hospital of PLA Department of Pathology
 ( Yu Xiaoling ) - Qingdao University Medical College Department of Physiology and Pathophysiology

Abstract


Cisplatin is a widely used anticancer drug that has adverse effects on gastrointestinal function. Curcumin is a natural polyphenol extracted from the rhizome of turmeric that has a wide range of biological activities. The present study investigated the effects of cisplatin on gastric emptying in mice and examined whether these can be inhibited by curcumin. We found that pretreatment with curcumin (200?mg/kg/day) for 10?30 days partly inhibited the decreases in gastric emptying rate and body weight induced by cisplatin. Furthermore, cisplatin reduced acetylcholine (ACh) concentration and the messenger RNA (mRNA) level of ACh receptor (AChR) as well as acetylcholinesterase activity in the stomach of mice; caused ultrastructural damage to interstitial cells of Cajal (ICC); and altered the expression of c-kit/stem cell factor and the gap junction protein connexin 43 in ICC. Curcumin pretreatment inhibited the effects of cisplatin on ACh indicators and ICC. These results demonstrate that curcumin can protect against cisplatin-induced gastric emptying disorder and thus has therapeutic potential for alleviating this condition in cancer patients receiving cisplatin chemotherapy.

키워드

acetylcholine; cisplatin; curcumin; gastric emptying; interstitial cells of Cajal

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