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The Effects of Carob (Ceratonia siliqua L.) on Emotional Behavior Impairment and Metabolic Disorders Induced by Estrogen Deficiency in Rats

Journal of Medicinal Food 2020년 23권 9호 p.961 ~ 966
Ammari Mohamed, Othman Haifa, Rtibi Kais, Sakly Mohsen, Abdelmelek Hafedh,
소속 상세정보
 ( Ammari Mohamed ) - University of Carthage Faculty of Sciences of Bizerte
 ( Othman Haifa ) - University of Carthage Faculty of Sciences of Bizerte
 ( Rtibi Kais ) - University of Jendouba Higher Institute of Biotechnology of Beja
 ( Sakly Mohsen ) - University of Carthage Faculty of Sciences of Bizerte
 ( Abdelmelek Hafedh ) - University of Carthage Faculty of Sciences of Bizerte

Abstract


Carob (Ceratonia siliqua L.) contains a wide variety of polyphenols with high antioxidant properties. In this study, we investigated the effects of aqueous extract of carob pods (AECP) on emotional behavior impairments and metabolic disorders in ovariectomized (OVX) rats. Female Wistar rats were assigned to three groups: group 1, control non-OVX rats; group 2, OVX rats; and group 3, OVX rats orally treated with AECP (500?mg/kg) for15 days after ovariectomy. Elevated plus-maze and open-field tests were performed on the 26th and 27th post-ovariectomy days, respectively. Afterwards, the rats were anesthetized and their serums were collected for biochemical analysis. We found that AECP improved emotional behavior impairments revealed by elevated plus-maze and open-field tests in OVX rats. Moreover, ovariectomy significantly increased triglyceride, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase levels in the serum. AECP administration significantly reversed ovariectomy-induced biochemical alterations. Thus, we suggest that the AECP may have an anxiolytic-like effect and prevent biochemical disorders associated with menopause or ovariectomy.

키워드

anxiety; aqueous extract of carob pods; neuroprotective; ovariectomy; rat

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