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Chemical Characterization of Bioactive Components of Rosa canina Extract and Its Protective Effect on Dextran Sulfate Sodium-Induced Intestinal Bowel Disease in a Mouse Model

Journal of Medicinal Food 2020년 23권 10호 p.1109 ~ 1119
Wanes Dalanda, Jabri Mohamed-Amine, Tounsi Haifa, Rtibi Kais, Zouari Nacim, Hajji Najla, Jridi Mourad, Abdellaoui Afifa, Sebai Hichem,
소속 상세정보
 ( Wanes Dalanda ) - University of Jendouba Higher Institute of Biotechnology of Beja
 ( Jabri Mohamed-Amine ) - University of Jendouba Higher Institute of Biotechnology of Beja
 ( Tounsi Haifa ) - Pasteur Institute of Tunis Laboratory of Human and Experimental Pathological Anatomy
 ( Rtibi Kais ) - University of Jendouba Higher Institute of Biotechnology of Beja
 ( Zouari Nacim ) - University of Sfax National School of Engineers of Sfax Laboratory of Enzymatic Engineering and Microbiology
 ( Hajji Najla ) - University of Jendouba Higher Institute of Biotechnology of Beja
 ( Jridi Mourad ) - University of Sfax National School of Engineers of Sfax Laboratory of Enzymatic Engineering and Microbiology
 ( Abdellaoui Afifa ) - Pasteur Institute of Tunis Laboratory of Human and Experimental Pathological Anatomy
 ( Sebai Hichem ) - University of Jendouba Higher Institute of Biotechnology of Beja

Abstract


Rosa canina is a well-known medicinal plant used in folk remedy that alleviates various disorders, including inflammation, gastritis, and diarrhea. The objective of this investigation was to identify and quantify the phenolic components of R. canina methanolic extract (RCME) and to determine its protective action with dextran sulfate sodium (DSS)-generated mice colitis model. RCME chemical analysis was done using Liquid Chromatography?Electrospray Ionization?Tandem Mass Spectrometry, and experimental animals received RCME at different doses before colitis induction by oral DSS administration during 7 days. Another group received sulfasalazine as a positive control. Colitis damages and RCME benefits were assessed using histopathological and biochemical changes and improvements. Many phenolic compounds have been identified. In addition, the DSS intoxication induced an alteration of colonic epithelium associated with an oxidative stress state. DSS administration led to an increase or decrease of intracellular mediators such as free iron and ionizable calcium. RCME consumption effectively protected against colonic histological/biochemical alterations induced by DSS intoxication providing support for the traditional use of this plant.

키워드

colitis; dextran sulfate sodium; intestinal bowel disease; oxidative stress; Rosa canina

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