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Assessment of Polygonum odoratum Lour. Leaf Extract on Rat's Ileum Contraction and the Mechanisms Involved

Journal of Medicinal Food 2020년 23권 11호 p.1169 ~ 1175
Duangjai Acharaporn, Parseatsook Kwanchanok, Sajjapong Wittawas, Saokaew Surasak,
소속 상세정보
 ( Duangjai Acharaporn ) - University of Phayao School of Medical Sciences Division of Physiology
 ( Parseatsook Kwanchanok ) - University of Phayao School of Medical Sciences Department of Nutrition
 ( Sajjapong Wittawas ) - University of Phayao School of Medical Sciences Department of Nutrition
 ( Saokaew Surasak ) - University of Phayao School of Pharmaceutical Sciences Department of Pharmaceutical Care

Abstract


Vietnamese coriander (Polygonum odoratum Lour.) is a plant native to northern Thailand. The biological activities of P. odoratum Lour. extract (POE) include antibacterial, antiviral, and expectorant. However, the effect of POE on intestinal smooth muscle motility is unclear. The aim of this study was to evaluate the relaxant effects of POE on isolated rat ileum. Propranolol (1?μM), calcium chloride (1?20?mM), and Nω-nitro-l-arginine methylester (l-NAME, 100?μM) were used to investigate the mechanisms of action. The results showed that POE (0.01?5?mg/mL) reduced KCl-induced contraction. In addition, POE (1?mg/mL) reduced the contraction by propranolol and l-NAME and attenuated CaCl2-induced contractions. Our results indicate that the relaxation effect of POE on ileum contractions seems to involve nitric oxide and β-adrenergic pathways, and blockade of calcium influx. These findings provide a pharmacological basis for the traditional use of POE to treat gastrointestinal disorders such as irritable bowel syndrome or diarrhea.

키워드

calcium; l-NAME; Polygonum odoratum Lour.; propranolol; smooth muscle relaxants

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