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Alleviated Actions of Plantago albicans Extract on Lead Acetate-Produced Hepatic Damage in Rats Through Antioxidant and Free Radical Scavenging Capacities

Journal of Medicinal Food 2020년 23권 11호 p.1201 ~ 1215
Barkaoui Taha, Hamimed Selma, Bellamine Houda, Bankaji Insaf, Sleimi Noomene, Landoulsi Ahmed,
소속 상세정보
 ( Barkaoui Taha ) - Carthage University Faculty of Sciences of Bizerte Laboratory of Biochemistry and Molecular Biology
 ( Hamimed Selma ) - Carthage University Faculty of Sciences of Bizerte Laboratory of Biochemistry and Molecular Biology
 ( Bellamine Houda ) - Regional Hospital of Menzel Bourguiba Pathological Anatomy Service
 ( Bankaji Insaf ) - University of Carthage Faculty of Sciences of Bizerte Laboratory of Resources, Materials, Valorisation and Ecosystems
 ( Sleimi Noomene ) - University of Carthage Faculty of Sciences of Bizerte Laboratory of Resources, Materials, Valorisation and Ecosystems
 ( Landoulsi Ahmed ) - Carthage University Faculty of Sciences of Bizerte Laboratory of Biochemistry and Molecular Biology

Abstract


The aim of this study was to explore the possible protective mechanisms and to determine the antioxidant capacity of phenolic compounds extracted from Plantago albicans against lead acetate-induced hepatic injury. High performance liquid chromatography-photo diode array/electrospray ionization-mass spectrometry (HPLC-PDA/ESI-MS) assay was used to identify the P. albicans extract phenolic compounds. Animals received 100?mg of lead acetate/kg of body weight (bw) in the drinking water for a period of 30 days. The other groups of rats were orally administered with silymarin (300?mg/kg bw) or the P. albicans extract at two doses (100 and 300?mg/kg of bw), once daily, by gastric gavage for the same time. The P. albicans exhibited high total phenolic, flavonoid, and anthocyanin contents. The antioxidant in vitro activity demonstrated that the P. albicans exhibits an important effect against deleterious reactive species. The in vivo results showed that P. albicans prevented the lead acetate-induced significant changes on serum and liver lipid levels. In contrast, P. albicans succeeded in improving the biochemical parameters of serum and liver bringing them closer to the normal values of the control group. It also significantly promoted (P?

키워드

hepatotoxicity; HPLC-PDA/ESI-MS method; lead acetate; oxidative stress; Plantago albicans; rat

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