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Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model

Journal of Medicinal Food 2020년 23권 12호 p.1231 ~ 1237
Jeon Hyong-Jun, 김희영, 배창환, 이유경, 김승태,
소속 상세정보
 ( Jeon Hyong-Jun ) - Pusan National University School of Korean Medicine Department of Korean Medical Science
김희영 ( Kim Hee-Young ) - Pusan National University Korean Medicine Research Center for Healthy Aging
배창환 ( Bae Chang-Hwan ) - Pusan National University School of Korean Medicine Department of Korean Medical Science
이유경 ( Lee Yu-Kyoung ) - Pusan National University School of Korean Medicine Department of Korean Medical Science
김승태 ( Kim Seung-Tae ) - Pusan National University School of Korean Medicine Department of Korean Medical Science

Abstract


Recent studies have determined that gastrointestinal function contributes to the control of Parkinson's disease (PD). Gastrointestinal dysfunction results in a leaky intestinal barrier, inducing inflammation in the gut. Korean red ginseng (KRG) is widely used for the treatment of numerous afflictions, including inflammation and neurodegenerative disease. We investigated changes in the intestinal tight junctions and proinflammatory cytokines in the colon, and alpha-synuclein (aSyn) in the colon and the substantia nigra (SN) of a PD mouse model. Eight-week-old male C57BL/6 mice were intraperitoneally administered 30?mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) once a day for 5 days, and orally given 100?mg/kg of KRG for 12 consecutive days. Alterations in the levels of occludin, zonula occludens-1 (ZO-1), tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in the colon, and the expressions of aSyn and tyrosine hydroxylase (TH) in the colon and the SN were evaluated. Oral administration of KRG significantly prevents the MPTP-induced motor dysfunction, and suppresses the MPTP-induced disruption of occludin and ZO-1, and suppresses the increase in TNF-α and IL-1β in the colon of mice. In addition, KRG prevents accumulation of aSyn and TH in the colon and the SN. These results suggest that KRG has the potential to prevent MPTP-induced leaky gut barrier, inflammation, and accumulation of aSyn.

키워드

alpha-synuclein; inflammation; Korean red ginseng; Parkinson's disease; tight junction

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