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Aucuparin Suppresses Bleomycin-Induced Pulmonary Fibrosis Via Anti-Inflammatory Activity

Journal of Medicinal Food 2021년 24권 2호 p.151 ~ 160
이수연, 박수연, 이경은, 김현식, 권재환, 김미정, 유호건,
소속 상세정보
이수연 ( Lee Soo-Yeon ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
박수연 ( Park Soo-Yeon ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
이경은 ( Lee Gyeong-Eun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
김현식 ( Kim Hyun-Sik ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
권재환 ( Kwon Jae-Hwan ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
김미정 ( Kim Mi-Jeong ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
유호건 ( Yoon Ho-Geun ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology

Abstract


Idiopathic pulmonary fibrosis (IPF) is a lung disease that results in scarring of the lungs for an unknown reason. Although many studies have been conducted on IPF, precise mechanisms and treatments have not yet been identified. In this study, we found that aucuparin, a natural product isolated from Sorbus aucuparia, inhibited pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. In the lung samples of mice treated with aucuparin, the gene expression of inflammation and macrophage activation markers was reduced compared to those treated with BLM alone. Moreover, aucuparin decreased the expression of profibrotic marker genes and increased the expression of antifibrotic marker genes. Finally, we observed that aucuparin significantly suppressed transforming growth factor-β-induced activation of inflammatory cytokine production and collagen synthesis from macrophages and fibroblasts, respectively. Taken together, these data demonstrate that aucuparin inhibits lung fibrosis via its anti-inflammatory action and support its potential to be a therapeutic drug for IPF treatment.

키워드

aucuparin; bleomycin; inflammation; pulmonary fibrosis

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