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The Effect of Antioxidant Agents on Cisplatin-Induced Laryngeal Histological Alterations in Rats

Journal of Medicinal Food 2021년 24권 2호 p.197 ~ 204
Basak Kayhan, Demir Mehmet Gokhan, Altintoprak Niyazi, Aydin Sedat,
소속 상세정보
 ( Basak Kayhan ) - Kartal Dr. Lutfi Kirdar Research Hospital Department of Pathology
 ( Demir Mehmet Gokhan ) - Istanbul University Istanbul Faculty of Medicine Department of Oral and Maxillofacial Surgery
 ( Altintoprak Niyazi ) - Medical Park Gebze Hospital Department of ENT
 ( Aydin Sedat ) - Istanbul University Istanbul Faculty of Medicine Department of Oral and Maxillofacial Surgery

Abstract


The larynx-related adverse effects that depend on cisplatin decrease patient comfort and many antioxidants have been used to eliminate these side effects. We aimed to identify the laryngeal mucosal changes imposed by cisplatin and investigated whether antioxidants, and their healing effects on these changes, may help reduce laryngeal complications in patients resulting from adverse effects in the larynx. A rat model was designed to evaluate the effects of cisplatin on the larynx and the protective role of antioxidants. Single-dose cisplatin was given both intraperitoneally alone and additionally administered with p-coumaric acid, melatonin, resveratrol, vitamin D, and oleic acid over 5 days. Whole larynges were dissected and evaluated histologically, histochemically, and immunohistochemically. Varying degrees of mucosal changes cisplatin group, but neither erosion nor an ulcer was observed. Numerous variable histological effects of antioxidants were observed on cisplatin exposed laryngeal mucosa. The most obvious effects of cisplatin were edema. The results of the study showed that resveratrol was the most preventive antioxidant agent against cisplatin-dependent mucosal changes. The highest increase in the Ki67 index was in the oleic acid group. Vitamin D increased stromal cyclooxygenase-2 expression that may have an effect on increasing mucosal damage.

키워드

antioxidants; cisplatin; histological alterations; larynx; mucositis

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