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Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study

Journal of Medicinal Food 2021년 24권 4호 p.333 ~ 341
Baba Yoshitake, Inagaki Shun, Nakagawa Sae, Kaneko Toshiyuki, Kobayashi Makoto, Takihara Takanobu,
소속 상세정보
 ( Baba Yoshitake ) - ITO EN Ltd.
 ( Inagaki Shun ) - ITO EN Ltd.
 ( Nakagawa Sae ) - ITO EN Ltd.
 ( Kaneko Toshiyuki ) - Tokyo Skytree Station Medical Clinic
 ( Kobayashi Makoto ) - ITO EN Ltd.
 ( Takihara Takanobu ) - ITO EN Ltd.

Abstract


l-theanine (γ-glutamylethylamide), an amino acid in green tea, has been shown to affect brain functions by relieving stress disorders, improving mood, and maintaining normal sleep. However, the cognitive functions for which theanine is effective are unclear. This study aimed to clarify which cognitive functions are positively affected by intake of l-theanine. A double-blind, randomized, placebo-controlled study was conducted. The subjects were Japanese men and women aged 50?69 years. Mini Mental State Examination-Japanese version score was 24 or higher. Cognitrax was used as a test battery for cognitive function. Evaluations were performed before the intervention, after a single dose of l-theanine, and after 12 weeks of regular intake. The single dose of l-theanine reduced the reaction time to attention tasks (Stroop test, Part 1), and it increased the number of correct answers and decreased the number of omission errors in working memory tasks (4-Part continuous performance test, Part 4). In conclusion, our study indicated that l-theanine may contribute to improving attention, thus enhancing working memory and executive functions.

키워드

attention; brain function; Cognitrax; executive function; green tea amino acid; working memory

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