잠시만 기다려 주세요. 로딩중입니다.

The Immunomodulatory Effects of Royal Jelly on Defending Against Bacterial Infections in the Caenorhabditis elegans Model

Journal of Medicinal Food 2021년 24권 4호 p.358 ~ 369
Natarajan Ojas, Angeloni Joseph T., Bilodeau Maxime F., Russi Kyle E., Dong Yuqing, Cao Min,
소속 상세정보
 ( Natarajan Ojas ) - Clemson University Department of Biological Sciences
 ( Angeloni Joseph T. ) - Clemson University Department of Biological Sciences
 ( Bilodeau Maxime F. ) - Clemson University Department of Biological Sciences
 ( Russi Kyle E. ) - Clemson University Department of Biological Sciences
 ( Dong Yuqing ) - Clemson University Department of Biological Sciences
 ( Cao Min ) - Clemson University Department of Biological Sciences

Abstract


Emerging evidence suggests that aging is associated with the deterioration of immunity, a term known as immunosenescence, which may lead to a higher incidence of infections in the elderly population. Our previous studies reported that supplementation of royal jelly (RJ) extended the lifespan of Caenorhabditis elegans (C. elegans), a nematode model. The aim of this study was to investigate the potential benefits of RJ supplementation on modulation of the innate immunity in C. elegans. Using Staphylococcus aureus (S. aureus; ATCC 25923) as the infection model, we showed that RJ supplementation from the egg hatching stage could protect C. elegans against the infection. Further mechanistic studies demonstrated that RJ coordinated pathways of IIS/DAF-16, p38 MAPK, and Wnt to modulate the innate immunity. In addition, when RJ was administrated to the aged C. elegans, the worms displayed prolonged survival time to a variety of bacterial infections compared with the nontreatment group. This result indicates the RJ may help delay the innate immunosenescence.

키워드

aging; Caenorhabditis elegans; innate immunity; royal jelly; Staphylococcus aureus

원문 및 링크아웃 정보

등재저널 정보