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Systemic and Adipose Tissue Redox Status in Sprague-Dawley Rats Fed Normal- and High-Fat Diets Supplemented with Lycopene

Journal of Medicinal Food 2021년 24권 4호 p.370 ~ 376
Senkus Katelyn E., Tan Libo, Crowe-White Kristi M.,
소속 상세정보
 ( Senkus Katelyn E. ) - University of Alabama Department of Human Nutrition
 ( Tan Libo ) - University of Alabama Department of Human Nutrition
 ( Crowe-White Kristi M. ) - University of Alabama Department of Human Nutrition

Abstract


Dietary patterns high in fat influence local and systemic oxidative stress through adipose tissue (AT) accrual and increased reactive oxygen species generation. Lycopene, a carotenoid with antioxidant functionality, may mitigate excess oxidative stress, yet the lipophilic nature of this compound may limit its functionality if sequestered by AT. Thus, it is critical to elucidate whether lycopene's efficacy is limited based on adiposity. The purpose of this study was to investigate the influence of lycopene-supplemented normal- and high-fat diets on systemic and AT redox status. Male Sprague-Dawley rats (n?=?18) were fed a 30% normal-fat (NFD) or 60% high-fat (HFD) purified diet supplemented with 100?mg of lycopene/day. Body weight and visceral AT mass, as well as serum and AT lycopene, lipid peroxides, and antioxidant capacity (AC), were assessed after 3, 7, and 10 weeks of supplementation. At week 10, AT mass was significantly higher (P?=?.028) in the HFD group, yet there were no significant differences in serum or AT lycopene concentrations or lipid peroxides between groups. Additionally, AT in the HFD group exhibited significantly greater lipophilic AC (27.6% higher, P?=?.031). Results suggest that excess adiposity did not negatively influence circulating lycopene, nor did it limit its antioxidant functionality.

키워드

adipose tissue; adipose tissue biology; carotenoids; high fat diet; lycopene; oxidative stress; redox status

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