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Cuphea calophylla var. mesostemon (Koehne) S.A. Graham: A Whole-Ethnopharmacological Investigation

Journal of Medicinal Food 2021년 24권 4호 p.394 ~ 410
Klider Lislaine Maria, Machado Camila Dias, de Almeida Valter Paes, Tirloni Cleide Adriane Signor, Marques Aline Aparecida Macedo, Palozi Rhanany Alan Calloi, Lorencone Bethania Rosa, Romao Paulo Vitor Moreira, Guarnier Lucas Pires, Gasparotto Arquimedes Junior,
소속 상세정보
 ( Klider Lislaine Maria ) - Ponta Grossa State University Pharmacy Department
 ( Machado Camila Dias ) - Ponta Grossa State University Pharmacy Department
 ( de Almeida Valter Paes ) - Ponta Grossa State University Pharmacy Department
 ( Tirloni Cleide Adriane Signor ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology
 ( Marques Aline Aparecida Macedo ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology
 ( Palozi Rhanany Alan Calloi ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology
 ( Lorencone Bethania Rosa ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology
 ( Romao Paulo Vitor Moreira ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology
 ( Guarnier Lucas Pires ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology
 ( Gasparotto Arquimedes Junior ) - Federal University of Grande Dourados Faculty of Health Sciences Laboratory of Electrophysiology and Cardiovascular Pharmacology

Abstract


Several species of Cuphea are used medicinally and are reported to have cardioprotective, diuretic, and antihypertensive properties. In Brazil, Cuphea species are collectively called “sete-sangrias” due to their similar appearances and are also used interchangeably for the same therapeutic purposes. So the aim of the study was to characterize morphoanatomy of leaves and stems, evaluate the safety, and investigate the diuretic, hypotensive, vasodilatory, and antioxidant properties of ethanol-soluble fraction of Cuphea calophylla var. mesostemon (Koehne) S.A. Graham. Initially, the morphoanatomical characterization of the leaves and stems of C. calophylla var. mesostemon was performed. For the pharmacological evaluation, the ethanol-soluble fraction from Cuphea calophylla (ESCC) was obtained and chemically characterized by high-performance liquid chromatography coupled with a diode array detector and tandem mass spectrometry techniques. Then, acute toxicity, diuretic, hypotensive, antioxidant, and vasodilatory effects were evaluated in Wistar rats. The main chemical compounds identified from ESCC were gallic acid derivatives, ellagitannins, and flavonoids. ESCC showed no acute toxic effect. ESCC showed no acute toxic effect and the estimated median lethal dose (LD50) was above 2000?mg/kg. ESCC treatment (30, 100, and 300?mg/kg) did not present any significant acute diuretic or hypotensive effects. However, an important reduction in the elimination of electrolytes was observed after the acute administration, and a significant increase in renal sodium elimination was observed after 7 days of treatment. In the cardiac tissue, the groups treated with ESCC presented significant increase in superoxide dismutase activity.

키워드

antioxidant; diuretic; hypertension; Lythraceae; morphoanatomy

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