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Curcumin Promotes Primary Oral Wound Healing in a Rat Model

Journal of Medicinal Food 2021년 24권 4호 p.422 ~ 430
Chaushu Liat, Gavrielov Marina Rahmanov, Chaushu Gabi, Zar Keidar, Vered Marilena,
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 ( Chaushu Liat ) - Tel Aviv University Faculty of Medicine Department of Periodontology and Implant Dentistry
 ( Gavrielov Marina Rahmanov ) - Tel Aviv University Faculty of Medicine Department of Periodontology and Implant Dentistry
 ( Chaushu Gabi ) - Tel Aviv University Faculty of Medicine Department of Oral and Maxillofacial Surgery
 ( Zar Keidar ) - Hebrew University Faculty of Dentistry Department of Oral and Maxillofacial Surgery
 ( Vered Marilena ) - Tel Aviv University Faculty of Medicine Department of Oral Pathology

Abstract


Curcumin is known as an anti-tumor, anti-aging, and wound healing promoter. The aim this study was to examine the effect of 2% curcumin paste application on primary wound healing in a palatal rat model. A mid-crestal incision was initiated on the maxillary alveolar ridge. A full thickness flap was raised on either side of the incision and was then repositioned and sutured. Experimental groups consisted of 2% curcumin (Cur), orabase (O), cut only (C), and intact control?no incision, no paste (N). Curcumin 2% and orabase were applied postoperatively every 12?h for 3 consecutive days. Rats were equally killed after 1 and 2 weeks. Histological data included?epithelial gap, inflammatory infiltrate, myofibroblasts, epithelial and connective tissue stem cell-related markers. Data were collected at two time points?1 and 2 weeks. There was no residual epithelial gap 1 week from incision in the Cur and O group vs. residual gap in the C group (P?=?.031). Curcumin 2% was associated with upregulated expression of epithelial-related markers (P?

키워드

curcumin; stem cell markers; wound healing

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