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DNA Polymorphism in 5'-flanking region of human apolipoprotein A1 and glutathione S-transferase mul gene in Koreans

Animal Cells and Systems 1997년 1권 2호 p.351 ~ 354
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Abstract


The distributions of G to A substitution (G?75?A) mutation in the human apolipoprotein A1 (APOAI) gene promoter region and glutathione S?tran?sferase Mu1 (GSTM1) gene deletion were examined in subjects with Korean population. The G?75?A mutation of APOA1 was genotyped by the polymerase chain reaction (PCR) and subsequent digestion of the PCR product using either Mspl or Mval (n=206). The observed numbers of GG, GA and AA genotypes were 132, 63 and 11, respectively. The allele frequencies of G and A were 0.794 and 0.206, respectively. The GSTM1 gene deletion was simply examined by the PCR amplification (n=106). The observed numbers of null type (GSTM1 *0/GSTM1 *0) and positive type were 55 and 51, respectively. The allele frequency of GSTM1*0 was 0.720

키워드

DNA polymorphism; Apolipoprotein A1; Glutathionine; S-transferase Mu1; Korean population

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