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Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish

Animal Cells and Systems 2021년 25권 1호 p.74 ~ 81
최영숙, 서혜민, Cho Mina, 김주희, 정학석, 이익수, 김민중,
소속 상세정보
최영숙 ( Choi Young-Sook ) - Sookmyung Women’s University Research Institute of Women’s Health
서혜민 ( Seo Hey-Min ) - Sookmyung Women’s University Research Institute of Women’s Health
 ( Cho Mina ) - Sookmyung Women’s University Department of Biological Sciences
김주희 ( Kim Joo-Hee ) - Sookmyung Women’s University Department of Biological Sciences
정학석 ( Chung Hak-Suk ) - Korea Institute of Science and Technology Biomedical Research Institute Center for Theragnosis
이익수 ( Lee Ick-Soo ) - Dankook University College of Medicine
김민중 ( Kim Min-Jung ) - Sookmyung Women’s University Department of Biological Science

Abstract


Excessive alcohol consumption causes the cellular and tissue damage. The toxic metabolites of ethanol are harmful to multiple organ systems, such as the central nervous system, skeletal muscles, and liver, and cause alcohol-induced diseases like cancer, as well as induce hepatotoxicity, and alcoholic myopathy. Alcohol exposure leads to a surge in hepatic alcohol metabolism and oxygen consumption, a decrease in hepatic ATP, and the rapid accumulation of lipid within hepatocytes. Several pathologies are closely linked to defective mitochondrial dynamics triggered by abnormal mitochondrial function and cellular homeostasis, raising the possibility that novel drugs targeting mitochondrial dynamics may have therapeutic potential in restoring cellular homeostasis in ethanol-induced hepatotoxicity. Rutin is a phytochemical polyphenol known to protect cells from cytotoxic chemicals. We investigated the effects of rutin on mitochondrial dynamics induced by ethanol. We found that rutin enhances mitochondrial dynamics by suppressing mitochondrial fission and restoring the balance of the mitochondrial dynamics. Mitochondrial elongation following rutin treatment of ethanol exposed cells was accompanied by reduced DRP1 expression. These data suggest that rutin plays an important role in remodeling of mitochondrial dynamics to alleviate hepatic steatosis and enhance mitochondrial function and cell viability.

키워드

Rutin; ethanol; DRP1; zebrafish; mitochondria

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