잠시만 기다려 주세요. 로딩중입니다.

Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis

Clinical and Experimental Otorhinolaryngology 2021년 14권 1호 p.43 ~ 49
Khalmuratova Roza, 신현우,
소속 상세정보
 ( Khalmuratova Roza ) - Seoul National University College of Medicine Department of Pharmacology
신현우 ( Shin Hyun-Woo ) - Seoul National University College of Medicine Department of Pharmacology

Abstract


Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients.

키워드

Osteitis; Chronic Rhinosinusitis; Inflammation; Osteoblasts; Osteoclasts; Cytokine

원문 및 링크아웃 정보

 

등재저널 정보