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Application of Animal Models in Diabetic Cardiomyopathy

Diabetes & Metabolism Journal 2021년 45권 2호 p.129 ~ 145
이왕수, 김재택,
소속 상세정보
이왕수 ( Lee Wang-Soo ) - Chung-Ang University College of Medicine Department of Internal Medicine
김재택 ( Kim Jae-Taek ) - Chung-Ang University College of Medicine Department of Internal Medicine

Abstract


Diabetic heart disease is a growing and important public health risk. Apart from the risk of coronary artery disease or hypertension, diabetes mellitus (DM) is a well-known risk factor for heart failure in the form of diabetic cardiomyopathy (DiaCM). Currently, DiaCM is defined as myocardial dysfunction in patients with DM in the absence of coronary artery disease and hypertension. The underlying pathomechanism of DiaCM is partially understood, but accumulating evidence suggests that metabolic derangements, oxidative stress, increased myocardial fibrosis and hypertrophy, inflammation, enhanced apoptosis, impaired intracellular calcium handling, activation of the renin-angiotensin-aldosterone system, mitochondrial dysfunction, and dysregulation of microRNAs, among other factors, are involved. Numerous animal models have been used to investigate the pathomechanisms of DiaCM. Despite some limitations, animal models for DiaCM have greatly advanced our understanding of pathomechanisms and have helped in the development of successful disease management strategies. In this review, we summarize the current pathomechanisms of DiaCM and provide animal models for DiaCM according to its pathomechanisms, which may contribute to broadening our understanding of the underlying mechanisms and facilitating the identification of possible new therapeutic targets.

키워드

Cardiomyopathies; Diabetes mellitus; Disease models, animal; Heart failure

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