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Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women

Diabetes & Metabolism Journal 2021년 45권 2호 p.175 ~ 182
이승은, 백지연, 한경도, 고은희,
소속 상세정보
이승은 ( Lee Seung-Eun ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
백지연 ( Baek Ji-Yeon ) - University of Ulsan College of Medicine Asan Medical Center Department of Internal Medicine
한경도 ( Han Kyung-Do ) - Catholic University College of Medicine Department of Biostatistics
고은희 ( Koh Eun-Hee ) - University of Ulsan College of Medicine Asan Medical Center Department of Internal Medicine

Abstract


Background: Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex and menopausal status.

Methods: A total of 1,700 adults from the 2010 Korean National Health and Nutrition Examination Survey were classified into metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) by body mass index and insulin resistance. Atopy was defined as a positive response to at least one aeroallergen. Multiple regression analysis was used to evaluate the risk of immunoglobulin E (IgE) elevation or atopy in relation to the degree of metabolic abnormality and obesity.

Results: In premenopausal women, total IgE was positively correlated with obesity and insulin resistance. MUNO participants had a higher risk of having elevated total IgE compared to MHNO participants (odds ratio [OR], 2.271; 95% confidence interval [CI], 1.201 to 4.294), while MHO participants did not show a significant difference (OR, 1.435; 95% CI, 0.656 to 3.137) in premenopausal women. MUNO, but not MHO was also associated with atopy (OR, 2.157; 95% CI, 1.284 to 3.625). In men and postmenopausal women, there was no significant difference between metabolic status, obesity, and atopy among groups.

Conclusion: Increased insulin resistance is associated with total IgE and atopy in premenopausal women but not in postmenopausal women or men.

키워드

Immunoglobulin E; Insulin resistance; Metabolic syndrome; Obesity

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