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An up-to-date review on chemistry and biological activities of Senna occidentalis (L.) Link Family: Leguminosae

Oriental Pharmacy and Experimental Medicine 2020년 20권 3호 p.263 ~ 278
Singh Harpreet, Chahal Piyush, Mishra Amrita, Mishra Arun Kumar,
소속 상세정보
 ( Singh Harpreet ) - IFTM University School of Pharmaceutical Sciences
 ( Chahal Piyush ) - IFTM University School of Pharmaceutical Sciences
 ( Mishra Amrita ) - IFTM University School of Pharmaceutical Sciences
 ( Mishra Arun Kumar ) - IFTM University School of Pharmaceutical Sciences

Abstract


Senna occidentalis (L.) Link Family: Leguminosae, one of the important Ayurvedic plants, to treat various ailments. The current review embarks on the detected secondary metabolites, biological properties and toxicological aspects of extracts of S. occidentalis (L.) Link. With an aim to encourage the recent and advanced research on extracts, the present review is presented. The traditional medicinal importance of S. occidentalis (L.) Link has been identified in tropical and subtropical regions to treat various ailments. All the available informations on S. occidentalis (L.) Link was collected via electronic search (using Pubmed, SciFinder, Scirus, Google Scholar, Agricola and Web of Science) and literature study done at library. About 38 phytocompounds have been isolated from S. occidentalis (L.) Link; the most important includes anthraquinones, flavonoid glycosides, xanthones, tetrahydro anthracenes, terpenes and phytosterol etc. In vivo biological studies of the extracts show that S. occidentalis (L.) Link possesses analgesic, anthelmintic, antidiabetic, anticonvulsant, antitrypanosomal, antioxidant, hepatoprotective, myeloprotective, wound healing, anticancer, anti-inflammatory and larvicidal activity. The extracts need to be further investigated to describe the extent of the biological effects, most advantageous dosage required, and mechanisms of action behind biological effects, safety profile and probable side effects. Moreover, clinical studies are required to support the curative potential of S. occidentalis (L.) Link.

키워드

Secondary metabolites; Senna occidentalis (L.) Link; Phytocompounds

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