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Toxicological evaluation, brine shrimp lethality assay, in vivo and ex vivo antioxidant assessment followed by GC?MS study of the extracts obtained from Olax psittacorum (Lam.) Vahl

Oriental Pharmacy and Experimental Medicine 2020년 20권 3호 p.303 ~ 325
Majumder Raja, Adhikari Lopamudra, Hossain Chowdhury Mobaswar, Dhara Moonmun, Sahu Jinamitra,
소속 상세정보
 ( Majumder Raja ) - Siksha ‘O’ Anusandhan University School of Pharmaceutical Sciences Department of Pharmaceutical Analysis
 ( Adhikari Lopamudra ) - Siksha ‘O’ Anusandhan University School of Pharmaceutical Sciences Department of Pharmaceutical Analysis
 ( Hossain Chowdhury Mobaswar ) - Principal of Bengal School of Technology College of Pharmacy
 ( Dhara Moonmun ) - Siksha ‘O’ Anusandhan University School of Pharmaceutical Sciences Department of Pharmaceutical Analysis
 ( Sahu Jinamitra ) - Siksha ‘O’ Anusandhan University IMS and SUM Hospital Department of Pathology

Abstract


Olax psittacorum (Lam.) Vahl. has versatile ethnopharmacological healing property in addition with incomplete research are adequate pieces of information to support the choice of the plant to build up proper data in acute and sub-chronic toxicological, cytotoxicity with ex vivo and in vivo antioxidant profile as well as qualitative analytical illustration through GC?MS of the selected extracts obtained from different parts of the plant. We have extracted leaf methanolic extract (LME), stem methanolic extract (SME), stem aqueous extract (SAE) and fruits aqueous extract (FrAE) for the above mentioned respective studies. OECD guideline 420 and 407, brine shrimp lethality (BSLA), lipid peroxidation, catalase assay was conducted to gather information on toxicity, cytotoxicity, and antioxidant properties respectively. BSLA study indicates that LME may be a good choice to develop as an anticancer drug for future perspective (LC50?=?41.88 μg/ml). Both LME and SME have been selected for ex vivo and in vivo antioxidant analysis on the basis of their low toxicity and GCMS analysis. Moreover, in vivo lipidperoxidation as well as catalase assay both having significant difference (P?

키워드

Acute and repeated oral dose toxicity study; Pathological investigation; BSLA (brine shrimp lethality assay); In vivo and ex vivo antioxidant; GCMS evaluation

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