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Comparative pharmacologic profiles of leaves and hypocotyls of a mangrove plant: Bruguiera gymnorrhiza

Oriental Pharmacy and Experimental Medicine 2020년 20권 3호 p.395 ~ 403
Golder Mimi, Sadhu Samir Kumar, Biswas Biswajit, Islam Tannami,
소속 상세정보
 ( Golder Mimi ) - Khulna University Life Science School Pharmacy Discipline
 ( Sadhu Samir Kumar ) - Khulna University Life Science School Pharmacy Discipline
 ( Biswas Biswajit ) - Khulna University Life Science School Pharmacy Discipline
 ( Islam Tannami ) - Khulna University Life Science School Pharmacy Discipline

Abstract


Ethanolic extracts of leaves and hypocotyls of a mangrove plant, Bruguiera gymnorrhiza (Family Rhizophoraceae), were investigated to identify the presence of different phytochemicals and to assess the antihyperglycemic, antidiarrheal, analgesic and antioxidative activity in the current study. Oral glucose tolerance test (OGTT) was performed to investigate the in vivo antihyperglycemic activity and leaves extract (LE) was found to possess significant antihyperglycemic property compared to hypocotyl extract (HE). Therefore, the leaves extract was considered for α-Glucosidase enzyme inhibitory activity test and substantial α-glucosidase enzyme inhibitory property was observed with an IC50 (concentration required to inhibit 50% enzyme) value of 2.670. Antioxidative activity of plant extracts was tested in vitro by evaluating their ability to scavenge DPPH, hydrogen peroxide and hydroxyl radical as well as superoxide anions. In all cases, LE showed greater activity than HE. In addition, LE demonstrated higher amount of total phenolics, flavonoids and tannins indicating higher antioxidant effect compared to HE. For the evaluation of antidiarrheal effect in castor oil induced diarrheal mice, both extracts showed significant inhibition of defecation at doses 250 and 500 mg/kg body weight. Finally, for acetic acid-induced writhing method to evaluate the analgesic activity, significant percentage inhibition of writhing (P?

키워드

Bruguiera gymnorrhiza; Antihyperglycemic; Antioxidant; Analgesic; Antidiarrheal

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