잠시만 기다려 주세요. 로딩중입니다.

Investigation of antinociceptive, anti-inflammatory and thrombolytic activity of Caesalpinia digyna (Rottl.) leaves by experimental and computational approaches

Oriental Pharmacy and Experimental Medicine 2020년 20권 3호 p.451 ~ 459
Emon Nazim Uddin, Jahan Israt, Sayeed Mohammed Aktar,
소속 상세정보
 ( Emon Nazim Uddin ) - Bangladesh International Islamic University Chittagong Department of Pharmacy
 ( Jahan Israt ) - Bangladesh International Islamic University Chittagong Department of Pharmacy
 ( Sayeed Mohammed Aktar ) - Bangladesh International Islamic University Chittagong Department of Pharmacy

Abstract


The study aimed to report in vitro thrombolytic and in vivo anti-nociceptive activity of methanolic extract of Caesalpinia digyna (MECD) followed by in silico PASS prediction, ADME analysis with toxicity and molecular docking study of antinociception (Cox-1, Cox-2) and thrombolytic (Tissue plasminogen activator). The clot lysis of human blood for thrombolytic study, acetic acid induced writing and formalin-induced licking in mice at several doses (50, 100, 200 and 400 mg/kg, b.w.; p.o.) of MECD for anti-inflammatory and antinoceptive activities were performed. In thrombolytic study, a significant 32.78% (P?

키워드

Antinociceptive; Caesalpinia digyna; Thrombolytic; Caesalpinine A; Caesalpinine C; Molecular docking

원문 및 링크아웃 정보

등재저널 정보