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Attempts to enhance the anti-cancer activity of curcumin as a magical oncological agent using transdermal delivery

Oriental Pharmacy and Experimental Medicine 2021년 21권 1호 p.15 ~ 29
Abdel-Hafez Salma M., Hathout Rania M., Sammour Omaima A.,
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 ( Abdel-Hafez Salma M. ) - Ain Shams University Faculty of Pharmacy Department of Pharmaceutics and Industrial Pharmacy
 ( Hathout Rania M. ) - Ain Shams University Faculty of Pharmacy Department of Pharmaceutics and Industrial Pharmacy
 ( Sammour Omaima A. ) - Ain Shams University Faculty of Pharmacy Department of Pharmaceutics and Industrial Pharmacy

Abstract


For the past few years, curcumin has drawn the attention of scientists in multidisciplinary fields related to oncology and therapeutics. However, despite its high potency, its delivery suffers from several limitations and challenges that hinders the complete benefit from this magical molecule. Accordingly, this review demonstrates the several attempts and endeavors that the scientists exerted in order to delivery this molecule successfully through the transdermal route. We believe that the transdermal route of delivery of drugs can pose a new platform of targeting solid tumors such as the breast carcinoma so that applying a transdermal patch over the skin or the membrane covering the solid tumor can provide a means of the cure.

키워드

Curcumin; Oncology; Cancer; Transdermal; Delivery systems

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